{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T05:21:47Z","timestamp":1784092907854,"version":"3.55.0"},"reference-count":17,"publisher":"Wiley","issue":"14","license":[{"start":{"date-parts":[[2023,3,26]],"date-time":"2023-03-26T00:00:00Z","timestamp":1679788800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Thoracic Cancer"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Hypertrophic osteoarthropathy (HOA) is a paraneoplastic syndrome, the exact pathogenesis of which remains to be elucidated. The case of a 69\u2010year\u2010old man who developed intractably painful HOA secondary to lung cancer is presented. Contrast\u2010enhanced computed tomography of the chest showed an 80\u2010mm solid nodule with a large low\u2010density area. The patient was diagnosed as having stage IIIA undifferentiated non\u2013small cell lung cancer. The combination of carboplatin and paclitaxel with bevacizumab reduced tumor size and plasma vascular endothelial growth factor (VEGF) levels, relieving his leg pain. On immunohistochemical examination, lung cancer cells were positive for VEGF. A hypoxic tumor microenvironment may have caused some lung cancer cells to express hypoxia\u2010inducible factor\u20101\u03b1, which contributed, at least in part, to the production of VEGF. The deep dermis vessels showed proliferation in the shin, with their thickened walls positive for VEGF. These findings may encourage investigators to explore novel management strategies for painful HOA.<\/jats:p>","DOI":"10.1111\/1759-7714.14869","type":"journal-article","created":{"date-parts":[[2023,3,27]],"date-time":"2023-03-27T06:47:40Z","timestamp":1679899660000},"page":"1320-1324","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Hypertrophic osteoarthropathy associated with lung cancer: Possible links among hypoxia\u2010inducible factor\u20101\u03b1, vascular endothelial growth factor, and hypervascularization"],"prefix":"10.1111","volume":"14","author":[{"given":"Ryuta","family":"Tagawa","sequence":"first","affiliation":[{"name":"Department of Respiratory Medicine Sasebo City General Hospital  Nagasaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4993-1837","authenticated-orcid":false,"given":"Hiroshi","family":"Soda","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Sasebo City General Hospital  Nagasaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yosuke","family":"Dotsu","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Sasebo City General Hospital  Nagasaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroaki","family":"Senju","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Senju Hospital  Nagasaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Irifune","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Sasebo City General Hospital  Nagasaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masataka","family":"Yoshida","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Sasebo City General Hospital  Nagasaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shota","family":"Nakashima","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Sasebo City General Hospital  Nagasaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asuka","family":"Umemura","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Sasebo City General Hospital  Nagasaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keisuke","family":"Iwasaki","sequence":"additional","affiliation":[{"name":"Department of Pathology Sasebo City General Hospital  Nagasaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2414-8344","authenticated-orcid":false,"given":"Hirokazu","family":"Taniguchi","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Nagasaki University Graduate School of Biomedical Sciences  Nagasaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinnosuke","family":"Takemoto","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Nagasaki University Graduate School of Biomedical Sciences  Nagasaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuichi","family":"Fukuda","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Sasebo City General Hospital  Nagasaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Mukae","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Nagasaki University Graduate School of Biomedical Sciences  Nagasaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,3,26]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1843.2010.01769.x"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1080\/17843286.2016.1152672"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.1565"},{"key":"e_1_2_6_5_1","first-page":"57","article-title":"Vascular endothelial growth factor and hypertrophic osteoarthropathy","volume":"18","author":"Silveira LH","year":"2000","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(87)91132-9"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature21706"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.94.2.663"},{"key":"e_1_2_6_9_1","first-page":"614","article-title":"Circulating vascular endothelial growth factor concentrations in a case of pulmonary hypertrophic osteoarthropathy. 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