{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T19:41:50Z","timestamp":1790624510289,"version":"4.1.0"},"reference-count":44,"publisher":"Wiley","issue":"15","license":[{"start":{"date-parts":[[2023,4,2]],"date-time":"2023-04-02T00:00:00Z","timestamp":1680393600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100010246","name":"Postdoctoral Science Foundation of Jiangsu Province","doi-asserted-by":"publisher","award":["2018K049A"],"award-info":[{"award-number":["2018K049A"]}],"id":[{"id":"10.13039\/501100010246","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004608","name":"Natural Science Foundation of Jiangsu Province","doi-asserted-by":"publisher","award":["BK20210146"],"award-info":[{"award-number":["BK20210146"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Thoracic Cancer"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Our research aimed to evaluate the effectiveness of first\u2010line immune checkpoint inhibitors (ICIs) with etoposide and platinum (EP) for extensive\u2010stage small cell lung cancer (ES\u2010SCLC) and identify prognostic factors, as real\u2010world outcomes and the inconsistency of PD\u20101 and PD\u2010L1 inhibitors are uncertain.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We selected ES\u2010SCLC patients in three centers and conducted a propensity score\u2010matched analysis. The Kaplan\u2013Meier method and Cox proportional hazards regression were conducted to compare the survival outcomes. We also performed univariate and multivariate Cox regression analyses to investigate predictors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 236 patients included, 83 pairs of cases were matched. The EP plus ICIs cohort had a longer median overall survival (OS) (17.3\u2009months) than the EP cohort (13.4\u2009months) (hazard ratio [HR], \u20090.61 [0.45, 0.83]; <jats:italic>p<\/jats:italic>\u2009=\u20090.001). The median progression\u2010free survival (PFS) was also longer in the EP plus ICIs cohort (8.3\u2009months) than in the EP cohort (5.9\u2009months) (HR, \u2009\u20090.44 [0.32, 0.60]; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). The EP plus ICIs group had a higher objective response rate (ORR) (EP: 62.3%, EP\u2009+\u2009ICIs: 84.3%, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Multivariate analysis presented that liver metastases (HR, 2.08; <jats:italic>p<\/jats:italic>\u2009=\u20090.018) and lymphocyte\u2013monocyte ratio (LMR) (HR, 0.54; <jats:italic>p<\/jats:italic>\u2009=\u20090.049) were independent prognostic factors for OS, and performance status (PS) (HR, 2.11; <jats:italic>p<\/jats:italic>\u2009=\u20090.015), liver metastases (HR, 2.64; <jats:italic>p<\/jats:italic>\u2009=\u20090.002), and neutrophil\u2010lymphocyte ratio (NLR) (HR, 0.45; <jats:italic>p<\/jats:italic>\u2009=\u20090.028) were for PFS in patients with chemo\u2010immunotherapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our real\u2010world data demonstrated that ICIs with chemotherapy as the first\u2010line setting for ES\u2010SCLC are effective and safe. PS, liver metastases, and inflammatory markers could serve as valuable risk factors.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1759-7714.14874","type":"journal-article","created":{"date-parts":[[2023,4,3]],"date-time":"2023-04-03T01:49:42Z","timestamp":1680486582000},"page":"1327-1338","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Clinical impact of first\u2010line <scp>PD<\/scp>\u20101 or <scp>PD\u2010L1<\/scp> inhibitors combined with chemotherapy in extensive\u2010stage <scp>small cell lung cancer<\/scp> patients: A real\u2010world multicenter propensity score\u2010matched study"],"prefix":"10.1111","volume":"14","author":[{"given":"Jingyuan","family":"Xie","sequence":"first","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine, Affiliated Jinling Hospital, Medical School Nanjing University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4466-3602","authenticated-orcid":false,"given":"Mo","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine, Jinling Hospital Jinling Clinical College of Nanjing Medical University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hedong","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine, Affiliated Jinling Hospital, Medical School Nanjing University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine, Affiliated Jinling Hospital, Medical School Nanjing University  Nanjing 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China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4979-4131","authenticated-orcid":false,"given":"Yong","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine, Affiliated Jinling Hospital, Medical School Nanjing University  Nanjing China"},{"name":"Department of Respiratory and Critical Care Medicine, Jinling Hospital Jinling Clinical College of Nanjing Medical University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinjun","family":"Ye","sequence":"additional","affiliation":[{"name":"Department of Radiotherapy, Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research Nanjing Medical University Affiliated Cancer Hospital  Nanjing 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