{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T07:07:31Z","timestamp":1768288051761,"version":"3.49.0"},"reference-count":40,"publisher":"Wiley","issue":"17","license":[{"start":{"date-parts":[[2023,4,27]],"date-time":"2023-04-27T00:00:00Z","timestamp":1682553600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Thoracic Cancer"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Circular RNAs (circRNAs) are associated with propofol\u2010mediated inhibitory effect on non\u2010small cell lung cancer (NSCLC) progression. Circular hsa_circ_0003028 (circ_0003028) exerts a tumor\u2010promoting role in NSCLC. However, it is unclear whether propofol can mediate NSCLC progression via regulating circ_0003028 expression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 36 NSCLC patients were recruited in the study. Cell viability, proliferation, apoptosis, migration, and invasion were determined by 3\u2010(4,5\u2010dimethylthiazol\u20102\u2010yl)\u20102,5\u2010diphenyltetrazolium bromide (MTT), colony formation, flow cytometry, and transwell assays. Relative expression of circ_0003028 in NSCLC samples and cells was detected by quantitative real\u2010time polymerase chain reaction (RT\u2010qPCR). Analysis of the latent binding of circ_0003028 to miR\u20101305 was done by bioinformatic analysis and confirmed by luciferase reporter and RNA immunoprecipitation (RIP) assays. Xenografting in mice was done to verify the relationship between propofol and circ_0003028.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Significant upregulation of circ_0003028 was detected in NSCLC samples and cells. Functionally, propofol treatment reduced circ_0003028 expression in NSCLC cells, and circ_0003028 overexpression impaired propofol\u2010mediated inhibitory effect on NSCLC cell proliferation, migration, and invasion. Interestingly, circ_0003028 could compete with miR\u20101305 as a competing endogenous RNA and upregulate CORO1C expression in NSCLC cells.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Propofol\u2010mediated inhibiting effect on NSCLC growth partly depended on the circ_0003028\/miR\u20101305\/CORO1C axis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1759-7714.14906","type":"journal-article","created":{"date-parts":[[2023,4,28]],"date-time":"2023-04-28T03:27:00Z","timestamp":1682652420000},"page":"1606-1617","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Propofol mediates non\u2010small cell lung cancer growth in part by regulating circ_0003028\u2010related mechanisms"],"prefix":"10.1111","volume":"14","author":[{"given":"Xiuli","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Anesthesiology The First People's Hospital of Lianyungang  Lianyungang 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