{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T02:31:22Z","timestamp":1783391482335,"version":"3.54.6"},"reference-count":13,"publisher":"Wiley","issue":"17","license":[{"start":{"date-parts":[[2023,5,2]],"date-time":"2023-05-02T00:00:00Z","timestamp":1682985600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Thoracic Cancer"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Thymic carcinoma is a highly malignant tumor and treatment options are limited. Lenvatinib, a novel multitargeted kinase inhibitor, has recently been approved for the treatment of unresectable thymic carcinoma. There are no reports of complete surgical resection after the administration of first\u2010line lenvatinib in advanced thymic carcinoma. A 50\u2010year\u2010old man visited our hospital because a computed tomography (CT) scan of the chest showed a large thymic squamous cell carcinoma. We suspected malignant pericardial effusion, invasion of the left upper lobe of the lung, and left mediastinal lymph node metastases. The patient was diagnosed with WHO classification stage IVb disease. Lenvatinib therapy was started at 24\u2009mg\/day as first\u2010line therapy. Gradual dose reduction to 16\u2009mg\/day was required because of hypertension, diarrhea, and palmar\u2010plantar erythrodysesthesia syndrome as side effects. Chest CT findings after 6\u2009months of lenvatinib therapy showed reduction of the main tumor, disappearance of the mediastinal lymph node metastases, and pericardial effusion. Complete salvage resection was successfully performed a month after discontinuation of lenvatinib. The patient has been disease\u2010free for 1\u2009year without adjuvant therapy. Lenvatinib therapy is one of the promising therapeutic options for thymic carcinoma and may make salvage surgery increasingly useful for advanced thymic carcinoma.<\/jats:p>","DOI":"10.1111\/1759-7714.14913","type":"journal-article","created":{"date-parts":[[2023,5,3]],"date-time":"2023-05-03T06:22:07Z","timestamp":1683094927000},"page":"1640-1643","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Successful resection after first\u2010line lenvatinib therapy in an advanced thymic carcinoma"],"prefix":"10.1111","volume":"14","author":[{"given":"Masatoshi","family":"Shimura","sequence":"first","affiliation":[{"name":"Division of General Thoracic Surgery, Department of Surgery Shinshu University School of Medicine  Matsumoto 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