{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T14:18:35Z","timestamp":1785161915559,"version":"3.55.0"},"reference-count":37,"publisher":"Wiley","issue":"21","license":[{"start":{"date-parts":[[2023,6,8]],"date-time":"2023-06-08T00:00:00Z","timestamp":1686182400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["20K17737"],"award-info":[{"award-number":["20K17737"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Thoracic Cancer"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Leukocyte immunoglobulin\u2010like receptor subfamily B member 4 (LILRB4\/ILT3) is an up\u2010and\u2010coming molecule that promotes immune evasion. We have previously reported that LILRB4 facilitates myeloid\u2010derived suppressor cells (MDSCs)\u2010mediated tumor metastasis in mice. This study aimed to investigate the impact of the LILRB4 expression levels on tumor\u2010infiltrating cells on the prognosis of non\u2010small cell lung cancer (NSCLC) patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We immunohistochemically evaluated the LILRB4 expression levels of completely resected 239 NSCLC specimens. Whether the blocking of LILRB4 on human PBMC\u2010derived CD33<jats:sup>+<\/jats:sup> MDSCs inhibited the migration ability of lung cancer cells was also examined using transwell migration assay.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The LILRB4 <jats:sup>high<\/jats:sup> group, in which patients with a high LILRB4 expression level on tumor\u2010infiltrating cells, showed a shorter overall survival (OS) (<jats:italic>p<\/jats:italic>\u2009=\u20090.013) and relapse\u2010free survival (RFS) (<jats:italic>p<\/jats:italic>\u2009=\u20090.0017) compared to the LILRB4 <jats:sup>low<\/jats:sup> group. Multivariate analyses revealed that a high LILRB4 expression was an independent factor for postoperative recurrence, poor OS and RFS. Even in the cohort background aligned by propensity score matching, OS (<jats:italic>p<\/jats:italic>\u2009=\u20090.023) and RFS (<jats:italic>p<\/jats:italic>\u2009=\u20090.0046) in the LILRB4 <jats:sup>high<\/jats:sup> group were shorter than in the LILRB4 <jats:sup>low<\/jats:sup> group. Some of the LILRB4 positive cells were positive for MDSC markers, CD33 and CD14. Transwell migration assay demonstrated that blocking LILRB4 significantly inhibited the migration of human lung cancer cells cocultured with CD33<jats:sup>+<\/jats:sup> MDSCs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Together, signals through LILRB4 on tumor\u2010infiltrating cells, including MDSCs, play an essential role in promoting tumor evasion and cancer progression, impacting the recurrence and poor prognosis of patients with resected NSCLC.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1759-7714.14991","type":"journal-article","created":{"date-parts":[[2023,6,8]],"date-time":"2023-06-08T22:31:41Z","timestamp":1686263501000},"page":"2057-2068","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Prognostic impact of LILRB4 expression on tumor\u2010infiltrating cells in resected non\u2010small cell lung cancer"],"prefix":"10.1111","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4465-122X","authenticated-orcid":false,"given":"Sakiko","family":"Kumata","sequence":"first","affiliation":[{"name":"Department of Thoracic Surgery, Institute of Development, Aging and Cancer Tohoku University  Sendai Japan"},{"name":"Department of Experimental Immunology, Institute of Development, Aging and Cancer Tohoku University  Sendai Japan"},{"name":"Division of Thoracic Surgery Miyagi Cancer Center Hospital  Natori Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirotsugu","family":"Notsuda","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Institute of Development, Aging and Cancer Tohoku University  Sendai Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei\u2010Tzu","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Experimental Immunology, Institute of Development, Aging and Cancer Tohoku University  Sendai Japan"},{"name":"Department of Biotechnology and Laboratory Science in Medicine National Yang Ming Chiao Tung University  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryoko","family":"Saito\u2010Koyama","sequence":"additional","affiliation":[{"name":"Department of Pathology Tohoku University Graduate School of Medicine  Sendai Japan"},{"name":"Department of Pathology, National Hospital Organization Sendai Medical Center  Sendai Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryota","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Institute of Development, Aging and Cancer Tohoku University  Sendai Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuyo","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Institute of Development, Aging and Cancer Tohoku University  Sendai 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