{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T04:38:28Z","timestamp":1790311108260,"version":"4.1.0"},"reference-count":20,"publisher":"Wiley","issue":"21","license":[{"start":{"date-parts":[[2023,6,8]],"date-time":"2023-06-08T00:00:00Z","timestamp":1686182400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Thoracic Cancer"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Rechallenge with platinum\u2010combination chemotherapy in patients with advanced non\u2010small cell lung cancer (NSCLC) after disease progression on platinum\u2010combination chemotherapy occasionally leads to a favorable response. The efficacy and safety of platinum\u2010combination chemotherapy with or without immune\u2010checkpoint inhibitor (ICI) for patients with recurrent NSCLC after surgery followed by adjuvant platinum\u2010doublet chemotherapy remains uncertain.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients who relapsed after surgery plus adjuvant platinum\u2010doublet chemotherapy and received platinum\u2010combination chemotherapy with or without ICI between April 2011 and March 2021 at four Nippon Medical School hospitals were retrospectively analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 177 patients who received adjuvant platinum\u2010doublet chemotherapy after surgery, a total of 30 patients who received platinum\u2010combination rechemotherapy with or without ICI after relapse were included in this study. Seven patients received ICI\u2010combined chemotherapy. The median disease\u2010free survival (DFS) after surgery was 13.6\u2009months. The objective response rate and disease\u2010control rate were 46.7% and 80.0%, respectively. The median progression\u2010free survival and overall survival were 10.2 and 37.5\u2009months, respectively. Patients with longer DFS (\u226512\u2009months) had a better prognosis than others. The most common grade\u2009\u22653 toxicity associated with this treatment was neutropenia (33%). Grade\u2009\u22653 immune\u2010related adverse events were pneumonitis (14%) and colitis (14%). Treatment\u2010related deaths did not occur in this study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Platinum\u2010combination chemotherapy with or without ICI for patients with postoperative recurrent NSCLC who previously received adjuvant platinum\u2010doublet chemotherapy was effective and safe. In particular, this therapy may be promising for patients with longer DFS.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1759-7714.14992","type":"journal-article","created":{"date-parts":[[2023,6,8]],"date-time":"2023-06-08T22:23:20Z","timestamp":1686263000000},"page":"2069-2076","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Platinum\u2010combination chemotherapy with or without immune\u2010checkpoint inhibitor in patients with postoperative recurrent non\u2010small cell lung cancer previously treated with adjuvant platinum\u2010doublet chemotherapy: A multicenter retrospective study"],"prefix":"10.1111","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9108-2050","authenticated-orcid":false,"given":"Kakeru","family":"Hisakane","sequence":"first","affiliation":[{"name":"Department of Pulmonary Medicine and Medical Oncology Nippon Medical School Tamanagayama Hospital  Tokyo 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