{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T03:31:02Z","timestamp":1784691062162,"version":"3.55.0"},"reference-count":35,"publisher":"Wiley","issue":"22","license":[{"start":{"date-parts":[[2023,6,20]],"date-time":"2023-06-20T00:00:00Z","timestamp":1687219200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Thoracic Cancer"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Vascular smooth muscle cells (VSMCs) are the predominant cell type of the aortic middle layer, the abnormal number or function of which has been demonstrated to have a role in thoracic aortic aneurysm (TAA). Here, this study aimed to identify the function of circ_0008285 in VSMC apoptosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Human VSMCs were treated with angiotensin II (Ang II) for functional experiments. Cell counting kit\u20108, 5\u2010ethynyl\u20102\u2032\u2010deoxyuridine (EdU), and flow cytometry were applied for function analysis. The interaction between miR\u2010150\u20105p and circ_0008285 or brain acid\u2010soluble protein 1 (BASP1) was also evaluated by dual\u2010luciferase reporter assay and RNA immunoprecipitation assay. Exosomes were isolated by the commercial kit.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A highly expressed circ_0008285 was observed in the aortic tissues of TAA patients and Ang\u2010II\u2010induced VSMCs. Circ_0008285 deficiency dramatically reversed Ang\u2010II\u2010induced proliferation arrest and apoptosis promotion in VSMCs. Circ_0008285 functionally targeted miR\u2010150\u20105p. MiR\u2010150\u20105p inhibition attenuated the inhibitory effects of circ_0008285 silencing on Ang\u2010II\u2010evoked apoptosis in VSMCs. BASP1 was verified to be a target of miR\u2010150\u20105p, and was proved to attenuate miR\u2010150\u20105p\u2010triggered apoptosis arrest in Ang\u2010II\u2010stimulated VSMCs. Additionally, extracellular circ_0008285 was packaged into exosomes, which could be transferred into the recipient cells.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Circ_0008285 silencing could suppress Ang\u2010II\u2010induced VSMCs apoptosis via miR\u2010150\u20105p\/BASP1 axis, adding further understanding of the pathogenesis of TAA.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1759-7714.15002","type":"journal-article","created":{"date-parts":[[2023,6,20]],"date-time":"2023-06-20T08:19:03Z","timestamp":1687249143000},"page":"2158-2167","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Circ_0008285 silencing suppresses angiotensin <scp>II<\/scp>\u2010induced vascular smooth muscle cell apoptosis in thoracic aortic aneurysm via <scp>miR<\/scp>\u2010150\u20105p\/<scp>BASP1<\/scp> axis"],"prefix":"10.1111","volume":"14","author":[{"given":"Leilei","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Surgery Heart Center of Henan Provincial People's Hospital, Central China Fuwai Hospital, Central China Fuwai Hospital of Zhengzhou University  Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziniu","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery Heart Center of Henan Provincial People's Hospital, Central China Fuwai Hospital, Central China Fuwai Hospital of Zhengzhou University  Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoqiang","family":"Quan","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery Heart Center of Henan Provincial People's Hospital, Central China Fuwai Hospital, Central China Fuwai Hospital of Zhengzhou University  Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhouliang","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery Heart Center of Henan Provincial People's Hospital, Central China Fuwai Hospital, Central China Fuwai Hospital of Zhengzhou University  Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery Heart Center of Henan Provincial People's Hospital, Central China Fuwai Hospital, Central China Fuwai Hospital of Zhengzhou University  Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,6,20]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00104-011-2242-1"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/1358863X18807760"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00104-016-0283-1"},{"key":"e_1_2_8_5_1","first-page":"4632","article-title":"YAP1 up\u2010regulation inhibits apoptosis of aortic dissection vascular smooth muscle cells","volume":"21","author":"Liu T","year":"2017","journal-title":"Eur Rev Med Pharmacol 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