{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T16:28:09Z","timestamp":1756312089583,"version":"3.40.5"},"reference-count":29,"publisher":"Wiley","issue":"24","license":[{"start":{"date-parts":[[2023,7,16]],"date-time":"2023-07-16T00:00:00Z","timestamp":1689465600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["20K09168","21K08889","21K16518"],"award-info":[{"award-number":["20K09168","21K08889","21K16518"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004325","name":"AstraZeneca","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004325","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010795","name":"Chugai Pharmaceutical","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010795","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100002491","name":"BMS","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100002491","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013170","name":"Ono Pharmaceutical","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013170","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Thoracic Cancer"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Several studies have reported that the high expression of programmed death\u2010ligand 1 (PD\u2010L1) within tumor cells predicts a poor prognosis. However, the relationship between the PD\u2010L1 expression and lymph node metastasis or driver mutations in lung cancer remains poorly understood.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 356 consecutive patients who underwent surgical resection for primary lung cancer were included in the study. There were 268 adenocarcinomas including 100 <jats:italic>EGFR<\/jats:italic> mutations, 67 squamous cell carcinomas (Sq), and 21 other histologies. The high expression of PD\u2010L1 was defined as a tumor proportion score (TPS) of \u226550. The relationship between the PD\u2010L1 expression and clinicopathological factors and recurrence\u2010free survival (RFS) was analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The PD\u2010L1 expression was high in 75 patients. It was significantly related to smoking history, Sq histology, driver mutation negative, elevated serum carcinoembryonic antigen levels, and lymph node metastasis. Among patients with driver mutations, a high PD\u2010L1 TPS was found in patients with <jats:italic>EGFR<\/jats:italic> G719X mutation. A significant difference in RFS was observed in adenocarcinoma patients. A multivariate analysis of adenocarcinoma cases revealed that tumor size and lymph node metastasis were independent prognostic factors for poor RFS, while the PD\u2010L1 expression was not. A logistic regression analysis revealed that the absence of driver mutations, lymph node metastasis, and a history of smoking were significantly associated with the high expression of PD\u2010L1.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Lymph node metastasis was positively related with the high expression of PD\u2010L1, resulting in poor RFS. A high PD\u2010L1 TPS was observed in patients with the EGFR G719X mutation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1759-7714.15031","type":"journal-article","created":{"date-parts":[[2023,7,17]],"date-time":"2023-07-17T04:40:14Z","timestamp":1689568814000},"page":"2467-2472","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Significance of programmed death\u2010ligand 1 expression in resected lung cancer and its relationship with <scp><i>EGFR<\/i><\/scp> mutation"],"prefix":"10.1111","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8327-3631","authenticated-orcid":false,"given":"Atsushi","family":"Osoegawa","sequence":"first","affiliation":[{"name":"Department of Thoracic and Breast Surgery Oita University Faculty of Medicine  Yufu Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miyuki","family":"Abe","sequence":"additional","affiliation":[{"name":"Department of Thoracic and Breast Surgery Oita University Faculty of Medicine  Yufu Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1171-9243","authenticated-orcid":false,"given":"Yohei","family":"Takumi","sequence":"additional","affiliation":[{"name":"Department of Thoracic and Breast Surgery Oita University Faculty of Medicine  Yufu Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takafumi","family":"Hashimoto","sequence":"additional","affiliation":[{"name":"Department of Thoracic and Breast Surgery Oita University Faculty of Medicine  Yufu Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Karashima","sequence":"additional","affiliation":[{"name":"Department of Thoracic and Breast Surgery Oita University Faculty of Medicine  Yufu Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michiyo","family":"Miyawaki","sequence":"additional","affiliation":[{"name":"Department of Thoracic and Breast Surgery Oita University Faculty of Medicine  Yufu Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9940-5897","authenticated-orcid":false,"given":"Kenji","family":"Sugio","sequence":"additional","affiliation":[{"name":"Department of Thoracic and Breast Surgery Oita University Faculty of Medicine  Yufu 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