{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:31:48Z","timestamp":1747182708949,"version":"3.40.5"},"reference-count":24,"publisher":"Wiley","issue":"25","license":[{"start":{"date-parts":[[2023,8,2]],"date-time":"2023-08-02T00:00:00Z","timestamp":1690934400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Thoracic Cancer"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Based on the results of the PACIFIC trial, maintenance with durvalumab has emerged as the standard treatment following concurrent chemoradiotherapy in patients with unresectable locally advanced non\u2010small cell lung carcinoma (NSCLC). However, adverse events attributed to durvalumab, especially lung injuries, including immune\u2010related adverse events, and radiation pneumonitis, are concerning. This study retrospectively investigated the factors related to lung injury in patients receiving the PACIFIC regimen.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients with unresectable locally advanced NSCLC who received durvalumab maintenance therapy following concurrent chemoradiotherapy at Yokohama City University Medical Centre between July 2018 and March 2022 were included. Clinical data, volume of normal lung receiving 20 or 5\u2009Gy or more (V20 or V5), planning target volume (PTV), and relative lung parenchyma volume in emphysematous lung receiving 20 or 5\u2009Gy or more (RLPV20 or 5; V20 or V5\/100\u2010percentage of low\u2010attenuation volume) were evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Performance status (PS), V20, V5, PTV, RLPV20, and RLPV5 were significantly higher in the lung injury group in the univariate analysis. Furthermore, RLPV20 was the most significant factor in the lung injury group in the multivariate analysis comprising PS, PTV, V20, and RLPV20.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>RLPV20 and RLPV5 are useful in estimating lung inflammation. RLPV20 could be considered the most reliable risk factor for maintenance therapy with durvalumab following concurrent chemoradiotherapy in patients with unresectable locally advanced NSCLC.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1759-7714.15042","type":"journal-article","created":{"date-parts":[[2023,8,3]],"date-time":"2023-08-03T03:19:54Z","timestamp":1691032794000},"page":"2601-2607","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Predictors of lung injury during durvalumab maintenance therapy following concurrent chemoradiotherapy in unresectable locally advanced non\u2010small cell lung carcinoma"],"prefix":"10.1111","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3585-5589","authenticated-orcid":false,"given":"Nobuyuki","family":"Hirama","sequence":"first","affiliation":[{"name":"Respiratory Disease Center Yokohama City University Medical Center  Yokohama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7056-4192","authenticated-orcid":false,"given":"Masaki","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Respiratory Disease Center Yokohama City University Medical Center  Yokohama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoshi","family":"Nagaoka","sequence":"additional","affiliation":[{"name":"Respiratory Disease Center Yokohama City University Medical Center  Yokohama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wataru","family":"Segawa","sequence":"additional","affiliation":[{"name":"Respiratory Disease Center Yokohama City University Medical Center  Yokohama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chihiro","family":"Sugimoto","sequence":"additional","affiliation":[{"name":"Respiratory Disease Center Yokohama City University Medical Center  Yokohama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hirokazu","family":"Nagayama","sequence":"additional","affiliation":[{"name":"Respiratory Disease Center Yokohama City University Medical Center  Yokohama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuntaro","family":"Hiro","sequence":"additional","affiliation":[{"name":"Respiratory Disease Center Yokohama City University Medical Center  Yokohama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yukihito","family":"Kajita","sequence":"additional","affiliation":[{"name":"Respiratory Disease Center Yokohama City University Medical Center  Yokohama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chihiro","family":"Maeda","sequence":"additional","affiliation":[{"name":"Respiratory Disease Center Yokohama City University Medical Center  Yokohama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sousuke","family":"Kubo","sequence":"additional","affiliation":[{"name":"Respiratory Disease Center Yokohama City University Medical Center  Yokohama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenichi","family":"Seki","sequence":"additional","affiliation":[{"name":"Respiratory Disease Center Yokohama City University Medical Center  Yokohama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshinori","family":"Nagahara","sequence":"additional","affiliation":[{"name":"Respiratory Disease Center Yokohama City University Medical Center  Yokohama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2365-144X","authenticated-orcid":false,"given":"Shuhei","family":"Teranishi","sequence":"additional","affiliation":[{"name":"Respiratory Disease Center Yokohama City University Medical Center  Yokohama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ken","family":"Tashiro","sequence":"additional","affiliation":[{"name":"Respiratory Disease Center Yokohama City University Medical Center  Yokohama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Hara","sequence":"additional","affiliation":[{"name":"Department of Pulmonology Yokohama City University Graduate School of Medicine  Yokohama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7064-320X","authenticated-orcid":false,"given":"Nobuaki","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Department of Pulmonology Yokohama City University Graduate School of Medicine  Yokohama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shigenobu","family":"Watanabe","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Fujisawa City Hospital  Fujisawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Makoto","family":"Kudo","sequence":"additional","affiliation":[{"name":"Respiratory Disease Center Yokohama City University Medical Center  Yokohama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takeshi","family":"Kaneko","sequence":"additional","affiliation":[{"name":"Department of Pulmonology Yokohama City University Graduate School of Medicine  Yokohama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,8,2]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-19-0221"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00408-020-00407-5"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-018-0777-1"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13164035"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1916623"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2021.39.15_suppl.8511"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/resp.13915"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2020.01.013"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2020.10.008"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19980301)82:5<842::AID-CNCR7>3.0.CO;2-L"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0360-3016(01)01685-6"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0167-8140(03)00119-1"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1259\/bjr\/32629867"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.5603\/PiAP.2016.0022"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.2147\/COPD.S101183"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.3934\/mbe.2021227"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.128.5.3212"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2004.02.005"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2004.02.015"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0360-3016(00)00648-9"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdz428"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1136\/jitc-2020-000840"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13014-021-01930-2"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/1878-0261.12891"}],"container-title":["Thoracic Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1759-7714.15042","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,6]],"date-time":"2023-09-06T07:54:36Z","timestamp":1693986876000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1759-7714.15042"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8,2]]},"references-count":24,"journal-issue":{"issue":"25","published-print":{"date-parts":[[2023,9]]}},"alternative-id":["10.1111\/1759-7714.15042"],"URL":"https:\/\/doi.org\/10.1111\/1759-7714.15042","archive":["Portico"],"relation":{},"ISSN":["1759-7706","1759-7714"],"issn-type":[{"type":"print","value":"1759-7706"},{"type":"electronic","value":"1759-7714"}],"subject":[],"published":{"date-parts":[[2023,8,2]]},"assertion":[{"value":"2023-06-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-07-06","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-08-02","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}