{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T19:21:21Z","timestamp":1787858481916,"version":"build-2784847793"},"reference-count":37,"publisher":"Wiley","issue":"26","license":[{"start":{"date-parts":[[2023,8,8]],"date-time":"2023-08-08T00:00:00Z","timestamp":1691452800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["MOST 109\u20102314\u2010B\u2010010\u2010023\u2010MY3"],"award-info":[{"award-number":["MOST 109\u20102314\u2010B\u2010010\u2010023\u2010MY3"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Thoracic Cancer"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>This study aimed to utilize an innovative method of integrating the 20 subvolume dose of left ventricle and the Tl\u2010201 single photon emission computed tomography (SPECT) with myocardial perfusion imaging (MPI) parameters in patients with left\u2010 and right\u2010sided breast cancer after radiation therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Female patients with breast cancer underwent SPECT MPI before commencing radiotherapy and 12\u2009months later were enrolled from January 2014 to December 2018. The images of CT simulation and SPECT MPI were integrated into the treatment planning system. The differences of doses and parameters of MPI in all cardiac subvolumes between left\u2010 and right\u2010sided breast cancer patients were analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Patients with left\u2010sided breast cancer (<jats:italic>n<\/jats:italic>\u2009=\u200961) received a higher radiation dose to the heart, left ventricular, and its territories and subvolumes, compared to patients with right\u2010sided breast cancer (<jats:italic>n<\/jats:italic>\u2009=\u200919). The 20\u2010segment analysis also showed statistically significant disparities in the average radiation doses received by the two groups. In different coronary artery territories, the end\u2010diastolic perfusion and end\u2010systolic perfusion showed a decrease in both sides, with no significant differences. However, the wall motion and wall thickening showed a significant decline in subregions within the left\u2010 and right\u2010sided coronary artery territories.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study demonstrates an innovative integrated method combining the left ventricular 20 regional doses with SPECT MPI which shows that left\u2010sided breast cancer patients receive a higher subvolume dose than right\u2010sided breast cancer patients. Further research is needed to confirm the potential impact on heart function after radiotherapy on both sides.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1759-7714.15056","type":"journal-article","created":{"date-parts":[[2023,8,9]],"date-time":"2023-08-09T04:31:45Z","timestamp":1691555505000},"page":"2696-2706","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Integrating subvolume dose and myocardial perfusion imaging parameters to assess the impact of radiation therapy on heart function in breast cancer patients: A comparative analysis between left\u2010 and right\u2010sided breast cancer"],"prefix":"10.1111","volume":"14","author":[{"given":"Shan\u2010Ying","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Biomedical Imaging and Radiological Sciences National Yang Ming Chiao Tung University  Taipei Taiwan"},{"name":"Department of Nuclear Medicine Far Eastern Memorial Hospital  New Taipei City 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