{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T20:06:15Z","timestamp":1760385975525,"version":"3.40.5"},"reference-count":31,"publisher":"Wiley","issue":"29","license":[{"start":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T00:00:00Z","timestamp":1692662400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["NO.81974361","NO.82272768"],"award-info":[{"award-number":["NO.81974361","NO.82272768"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Thoracic Cancer"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The absence of thyroid transcription factor 1 (TTF\u20101) is associated with a lower frequency of epidermal growth factor receptor (EGFR) mutations in lung adenocarcinoma (LUAD). The aim of this study was to assess the impact of TTF\u20101 expression on the clinical response to EGFR\u2010tyrosine kinase inhibitor (TKI) treatment in patients with advanced LUAD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The data of patients with advanced LUAD who were admitted to the Beijing Tiantan Hospital and Peking University Cancer Hospital (China) between April 2009 and May 2023 was retrospectively analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 227 patients diagnosed with advanced LUAD were included, of which 28.2% (64\/227) had TTF\u20101\u2010negative adenocarcinoma, while 54.6% (124\/227) harbored <jats:italic>EGFR<\/jats:italic> mutations. Negative TTF\u20101 expression significantly correlated with male sex (68.8% vs. 42.3%, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), history of heavy smoking (57.8% vs. 36.2%, <jats:italic>p<\/jats:italic>\u2009=\u20090.003), poorly differentiated tumors (86.5% vs. 43.2%, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), and lower frequency of <jats:italic>EGFR<\/jats:italic> mutations (26.6% vs. 65.6%, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) compared with TTF\u20101 positivity. Multivariable logistic regression showed that low prevalence of <jats:italic>EGFR<\/jats:italic> mutations (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) and male sex (<jats:italic>p<\/jats:italic>\u2009=\u20090.006) were independent predictive factors for the negative expression of TTF\u20101. Patients lacking TTF\u20101 also exhibited worse overall response rate (ORR; 23.5% vs. 54.2%, <jats:italic>p<\/jats:italic>\u2009=\u20090.019), disease control rate (DCR; 58.8<jats:italic>%<\/jats:italic> vs. 89.7%, <jats:italic>p<\/jats:italic>\u2009=\u20090.003), and median progression\u2010free survival (PFS; 2.9 vs. 11.6\u2009months, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) following treatment with EGFR\u2010TKIs compared to the TTF\u20101\u2010positive patients with <jats:italic>EGFR<\/jats:italic> mutations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Patients with TTF\u20101\u2010negative and <jats:italic>EGFR<\/jats:italic>\u2010mutant LUAD show a diminished response to EGFR\u2010TKIs.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1759-7714.15079","type":"journal-article","created":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T08:57:07Z","timestamp":1692694627000},"page":"2934-2940","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Thyroid transcription factor 1 (<scp>TTF<\/scp>\u20101) negativity as a predictor of unfavorable response to <scp>EGFR\u2010TKI<\/scp> therapy in advanced lung adenocarcinoma patients with <scp><i>EGFR<\/i><\/scp> mutations"],"prefix":"10.1111","volume":"14","author":[{"given":"Xiaosheng","family":"Ding","sequence":"first","affiliation":[{"name":"Department of Oncology Beijing Tiantan Hospital, Capital Medical University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weiwei","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Oncology PLA General Hospital  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bingxuan","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Sport Rehabilitation Shanxi Medical University  Taiyuan China"},{"name":"Department of Physical Education Shanxi Medical University  Taiyuan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9383-479X","authenticated-orcid":false,"given":"Hanxiao","family":"Chen","sequence":"additional","affiliation":[{"name":"Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Thoracic Oncology Peking University Cancer Hospital &amp; Institute  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jia","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pathology Beijing Tiantan Hospital, Capital Medical University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan","family":"An","sequence":"additional","affiliation":[{"name":"Department of Oncology Beijing Tiantan Hospital, Capital Medical University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lili","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Oncology Beijing Tiantan Hospital, Capital Medical University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weiran","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Oncology Beijing Tiantan Hospital, Capital Medical University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Oncology Beijing Tiantan Hospital, Capital Medical University  Beijing 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