{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T06:03:12Z","timestamp":1776405792630,"version":"3.51.2"},"reference-count":69,"publisher":"Wiley","issue":"31","license":[{"start":{"date-parts":[[2023,9,18]],"date-time":"2023-09-18T00:00:00Z","timestamp":1694995200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Thoracic Cancer"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The rearranged during transfection (RET) gene is one of the receptor tyrosine kinases and cell\u2010surface molecules responsible for transmitting signals that regulate cell growth and differentiation. In non\u2010small cell lung cancer (NSCLC), RET fusion is a rare driver gene alteration associated with a poor prognosis. Fortunately, two selective RET inhibitors (sRETi), namely pralsetinib and selpercatinib, have been approved for treating RET fusion NSCLC due to their remarkable efficacy and safety profiles. These inhibitors have shown the ability to overcome resistance to multikinase inhibitors (MKIs). Furthermore, ongoing clinical trials are investigating several second\u2010generation sRETis that are specifically designed to target solvent front mutations, which pose a challenge for first\u2010generation sRETis. The effective screening of patients is the first crucial step in the clinical application of RET\u2010targeted therapy. Currently, four methods are widely used for detecting gene rearrangements: next\u2010generation sequencing (NGS), reverse transcription\u2010polymerase chain reaction (RT\u2010PCR), fluorescence in situ hybridization (FISH), and immunohistochemistry (IHC). Each of these methods has its advantages and limitations. To streamline the clinical workflow and improve diagnostic and treatment strategies for RET fusion NSCLC, our expert group has reached a consensus. Our objective is to maximize the clinical benefit for patients and promote standardized approaches to RET fusion screening and therapy.<\/jats:p>","DOI":"10.1111\/1759-7714.15105","type":"journal-article","created":{"date-parts":[[2023,9,18]],"date-time":"2023-09-18T07:13:17Z","timestamp":1695021197000},"page":"3166-3177","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Expert consensus on the diagnosis and treatment of <scp>RET<\/scp> gene fusion <scp>non\u2010small<\/scp> cell lung cancer in <scp>China<\/scp>"],"prefix":"10.1111","volume":"14","author":[{"given":"Xingxiang","family":"Pu","sequence":"first","affiliation":[{"name":"The Second Department of Thoracic Oncology, Hunan Cancer Hospital\/The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University Central South University  Changsha People's Republic of 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