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A total of 8008 high\u2010quality cells were finally obtained for subsequent bioinformatic analysis, which were divided into 10 cell clusters further identified as B cells, T cells, myeloid cells, NK cells, and cancer cells. Such SCLC related genes as NOTCH1, MYC, TSC22D1, SOX4, BLNK, YBX3, VIM, CD8A, CD8B, and KLF6 were expressed in different degrees during differentiation of T and B cells. Different ligands and receptors between T, B and tumor cells almost interact through MHC II, IL\u201016, galectin, and APP signaling pathway.<\/jats:p>","DOI":"10.1111\/1759-7714.15145","type":"journal-article","created":{"date-parts":[[2023,11,28]],"date-time":"2023-11-28T00:38:35Z","timestamp":1701131915000},"page":"98-103","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Single\u2010cell <scp>RNA<\/scp> sequencing reveals immune microenvironment of small cell lung cancer\u2010associated malignant pleural effusion"],"prefix":"10.1111","volume":"15","author":[{"given":"Shuyan","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine West China Hospital of Sichuan University  Chengdu China"},{"name":"Division of Pulmonary Diseases, State Key Laboratory of Biotherapy of China West China Hospital, West China School of Medicine, Sichuan University  Chengdu 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