{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T16:22:16Z","timestamp":1784132536107,"version":"3.55.0"},"reference-count":6,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,12,14]],"date-time":"2023-12-14T00:00:00Z","timestamp":1702512000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Thoracic Cancer"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>IgG4\u2010related diseases are adverse events that occur after receiving treatment with immune checkpoint inhibitors (ICI). This study reports the first case of IgG4\u2010related retroperitoneal fibrosis after the administration of chemotherapy with nivolumab and ipilimumab (NI therapy). An 80\u2010year\u2010old man developed lower abdominal pain eight months after NI therapy was initiated. Although the primary lesion maintained its reduced size on computed tomography, there was an increase in the soft tissue shadows intensity around the abdominal aorta, bladder, and seminal vesicles, suggesting retroperitoneal fibrosis. Blood tests showed elevated IgG4 levels. Computed tomography\u2010guided biopsy of the retroperitoneum showed B cell\u2010dominant lymphocyte infiltration consistent with IgG4\u2010related retroperitoneal fibrosis and characteristic CD8\u2010positive lymphocyte infiltration, suggestive of the involvement of cytotoxic T cells. Based on the clinical, imaging, and pathological findings, the patient was diagnosed with IgG4\u2010related retroperitoneal fibrosis due to ICI. Immunotherapy discontinuation alone did not result in improvement; therefore, steroid therapy was initiated. In clinical practice, IgG4\u2010related retroperitoneal fibrosis can occur as an immune\u2010related adverse event when administering anti\u2010PD\u20101 and anti\u2010CTLA\u20104 antibodies for cancer immunotherapy. Early steroid therapy could be effective in controlling this immune\u2010related adverse event.<\/jats:p>","DOI":"10.1111\/1759-7714.15155","type":"journal-article","created":{"date-parts":[[2023,12,15]],"date-time":"2023-12-15T06:27:38Z","timestamp":1702621658000},"page":"104-107","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["<scp>IgG4<\/scp>\u2010related retroperitoneal fibrosis induced by nivolumab and ipilimumab in a patient with non\u2010small cell lung cancer: A case report"],"prefix":"10.1111","volume":"15","author":[{"given":"Masashi","family":"Nishimura","sequence":"first","affiliation":[{"name":"Division of Infectious Diseases and Respiratory Medicine, Department of Internal Medicine National Defense Medical College  Saitama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4026-7506","authenticated-orcid":false,"given":"Yoshifumi","family":"Kimizuka","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases and Respiratory Medicine, Department of Internal Medicine National Defense Medical College  Saitama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takunori","family":"Ogawa","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases and Respiratory Medicine, Department of Internal Medicine National Defense Medical College  Saitama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-7584-5880","authenticated-orcid":false,"given":"Motohiro","family":"Tsuchiya","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine National Defense Medical College  Saitama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiki","family":"Kato","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases and Respiratory Medicine, Department of Internal Medicine National Defense Medical College  Saitama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akira","family":"Matsukida","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases and Respiratory Medicine, Department of Internal Medicine National Defense Medical College  Saitama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shunya","family":"Igarashi","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases and Respiratory Medicine, Department of Internal Medicine National Defense Medical College  Saitama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koki","family":"Ito","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases and Respiratory Medicine, Department of Internal Medicine National Defense Medical College  Saitama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusuke","family":"Serizawa","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases and Respiratory Medicine, Department of Internal Medicine National Defense Medical College  Saitama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomomi","family":"Tanigaki","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases and Respiratory Medicine, Department of Internal Medicine National Defense Medical College  Saitama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuji","family":"Fujikura","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases and Respiratory Medicine, Department of Internal Medicine National Defense Medical College  Saitama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuka","family":"Katsurada","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine National Defense Medical College  Saitama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sho","family":"Ogata","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine National Defense Medical College  Saitama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akihiko","family":"Kawana","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases and Respiratory Medicine, Department of Internal Medicine National Defense Medical College  Saitama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,12,14]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"248","article-title":"IgG4\u2010related pleural disease in a patient with pulmonary adenocarcinoma under durvalumab treatment: a case report","volume":"5","author":"Terashima T","year":"2020","journal-title":"BMC Pulm Med"},{"key":"e_1_2_8_3_1","first-page":"638","article-title":"Review of IgG4\u2010related disease","volume":"42","author":"S\u00e1nchez\u2010Oro R","year":"2019","journal-title":"Gastroenterol Hepatol (N Y)"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-019-04352-1"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(06)68035-5"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-pathol-012513-104708"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.21.01440"}],"container-title":["Thoracic Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1759-7714.15155","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,18]],"date-time":"2024-01-18T04:21:45Z","timestamp":1705551705000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1759-7714.15155"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12,14]]},"references-count":6,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,1]]}},"alternative-id":["10.1111\/1759-7714.15155"],"URL":"https:\/\/doi.org\/10.1111\/1759-7714.15155","archive":["Portico"],"relation":{},"ISSN":["1759-7706","1759-7714"],"issn-type":[{"value":"1759-7706","type":"print"},{"value":"1759-7714","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,12,14]]},"assertion":[{"value":"2023-09-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication 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