{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T14:58:09Z","timestamp":1792681089561,"version":"4.5.0"},"reference-count":35,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,11,29]],"date-time":"2023-11-29T00:00:00Z","timestamp":1701216000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Thoracic Cancer"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Chemotherapy is an important approach for lung cancer patients. The study was designed to evaluate the feasibility of the compound probiotic supplements in improving the quality of life for lung cancer patients undergoing chemotherapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This randomized, double\u2010blind, placebo\u2010controlled trial enrolled chemotherapy\u2010naive patients with lung cancer who were scheduled to receive platinum\u2010based doublet chemotherapy. All eligible patients were randomly administered (1:1) compound probiotic supplements (group BP\u20101) or placebo (group C) for two chemotherapy cycles. The EORTC QLQ C30 questionnaire scores were evaluated before the first, second, and third cycles of chemotherapy. The primary endpoint was the difference in the EROTC QLQ C30 questionnaire score between the two groups after two cycles of chemotherapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 110 patients were recruited from March 2021 to January 2022. After undergoing two cycles of chemotherapy, group BP\u20101 were significantly better in various dimensions of the overall quality of life, role function, nausea and vomiting, appetite loss, constipation, and diarrhea relative to group C (76.90\u2009\u00b1\u200918.31 vs. 58.89\u2009\u00b1\u200917.17; 93.33\u2009\u00b1\u200911.58 vs. 85.93\u2009\u00b1\u200915.06; 0.00\u2009\u00b1\u20090.00 vs. 27.04\u2009\u00b1\u200929.15; 6.67\u2009\u00b1\u200913.53 vs. 22.22\u2009\u00b1\u200918.80; 0.95\u2009\u00b1\u20095.63 vs. 28.15\u2009\u00b1\u200922.42; 2.86\u2009\u00b1\u20099.47 vs. 15.56\u2009\u00b1\u200916.82;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05, respectively). The incidence of nausea and vomiting, appetite loss, constipation, and diarrhea in group BP\u20101 was significantly lower than in group C (0% vs. 71.43%, 16.67% vs. 57.14%, 2.38% vs. 63.27%, and 7.14% vs. 42.86%, respectively,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Compound probiotic supplements can improve the quality of life and relieve chemotherapy\u2010related gastrointestinal side effects for lung cancer patients receiving platinum\u2010based doublet chemotherapy. (Chinese Clinical Trial Registry: ChiCTR1800019269).<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/1759-7714.15177","type":"journal-article","created":{"date-parts":[[2023,11,29]],"date-time":"2023-11-29T06:08:52Z","timestamp":1701238132000},"page":"182-191","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Oral compound probiotic supplements can improve the quality of life for patients with lung cancer during chemotherapy: A randomized placebo\u2010controlled study"],"prefix":"10.1111","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8583-997X","authenticated-orcid":false,"given":"Hao","family":"Wei","sequence":"first","affiliation":[{"name":"Thoracic Oncology Ward, Cancer Center, West China Hospital Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiying","family":"Yue","sequence":"additional","affiliation":[{"name":"Department of Biotherapy, Cancer Center, West China Hospital Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jialong","family":"Han","sequence":"additional","affiliation":[{"name":"Thoracic Oncology Ward, Cancer Center, West China Hospital Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2836-7993","authenticated-orcid":false,"given":"Ping","family":"Chen","sequence":"additional","affiliation":[{"name":"Cancer Center  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke","family":"Xie","sequence":"additional","affiliation":[{"name":"Cancer Center, Sichuan Academy of Medical Sciences &amp; Sichuan Provincial People's Hospital, School of Medicine University of Electronic Science and Technology of China  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3316-7216","authenticated-orcid":false,"given":"Yu","family":"Sun","sequence":"additional","affiliation":[{"name":"Radiotherapy Physics &amp; Technology Center, Cancer Center, West China Hospital Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5496-8450","authenticated-orcid":false,"given":"Jiang","family":"Zhu","sequence":"additional","affiliation":[{"name":"Thoracic Oncology Ward, Cancer Center, West China Hospital Sichuan University  Chengdu China"},{"name":"Department of Medical Oncology, Shangjin branch of West China Hospital Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,11,29]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hoc.2016.08.005"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21166"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0277-5379(83)90418-2"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2021.107973"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2016.09.009"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1240537"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature17626"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mib.2010.12.003"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.3332\/ecancer.2018.868"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.4161\/cbt.8.6.7852"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-006-0040-y"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2012.03.012"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-10-1259"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200324181"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mds021"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00432-021-03554-1"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1080\/1040841X.2023.2233605"},{"issue":"4","key":"e_1_2_8_19_1","first-page":"1130","article-title":"Lactobacillus 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