{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T13:25:59Z","timestamp":1779110759695,"version":"3.51.4"},"reference-count":31,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,12,26]],"date-time":"2023-12-26T00:00:00Z","timestamp":1703548800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Thoracic Cancer"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>This study aimed to investigate the clinicopathological features and prognostic indicators of primary pulmonary adenoid cystic carcinoma (PACC).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Clinical data were collected from 64 primary PACC patients and analyzed retrospectively at the Tianjin Medical University General Hospital, the West China Hospital of Sichuan University, the First Affiliated Hospital of Guangxi Medical University, and the Bishan Hospital of Chongqing Medical University from January 2003 to August 2023. The 64 patients (28 males and 36 females) were aged from 20 to 73\u2009years, with a median age of 49\u2009years and an average age of 49.3\u2009years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Immunohistochemical staining showed that the tumors expressed CK7, S\u2010100 protein, CK5\/6, CD117, and p63. Seven patients underwent fluorescence in situ hybridization (FISH) testing and three were found to have myeloblastosis (MYB) gene translocation. In total, 53 patients underwent surgery, among whom 31 received only surgery and 22 received both surgery and postoperative chemoradiotherapy. In addition, 10 patients received chemoradiotherapy only, while one patient underwent treatment with traditional Chinese medicine. The overall survival rates in the first, third, and fifth years were 98.4%, 95.3%, and 87.5%, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Prognostic analysis revealed that age, tumor size, lymph node metastasis status, margin status, and choice of treatment modality significantly influenced the patients' prognosis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1759-7714.15202","type":"journal-article","created":{"date-parts":[[2023,12,27]],"date-time":"2023-12-27T07:24:37Z","timestamp":1703661877000},"page":"386-393","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Primary pulmonary adenoid cystic carcinoma: A clinicopathological study of 64 patients"],"prefix":"10.1111","volume":"15","author":[{"given":"Xiang","family":"Tan","sequence":"first","affiliation":[{"name":"Department of Medical Oncology, Cancer Center, West China Hospital Sichuan University  Chengdu China"},{"name":"Lung Cancer Center, West China Hospital Sichuan University  Chengdu China"},{"name":"Department of Thoracic Surgery The First Affiliated Hospital of Guangxi Medical University  Nanning China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tao","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery the Affiliated Hospital of Southwest Medical University  Luzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9211-2901","authenticated-orcid":false,"given":"Wang","family":"Shen","sequence":"additional","affiliation":[{"name":"Lung Cancer Center, West China Hospital Sichuan University  Chengdu China"},{"name":"Lung Cancer Center, West China Tianfu Hospital Sichuan University  Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheng","family":"Ai","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery Bishan Hospital of Chongqing Medical University  Chongqing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weilin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Lung Cancer Center, West China Tianfu Hospital Sichuan University  Chengdu China"},{"name":"Rehabilitation Medicine Center, West China Hospital Sichuan University  Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8757-0927","authenticated-orcid":false,"given":"Xiaojun","family":"Tang","sequence":"additional","affiliation":[{"name":"Lung Cancer Center, West China Hospital Sichuan University  Chengdu China"},{"name":"Lung Cancer Center, West China Tianfu Hospital Sichuan University  Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feng","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Cancer Center, West China Hospital Sichuan University  Chengdu China"},{"name":"Lung Cancer Center, West China Hospital Sichuan University  Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qinghua","family":"Zhou","sequence":"additional","affiliation":[{"name":"Lung Cancer Center, West China Hospital Sichuan University  Chengdu China"},{"name":"Lung Cancer Center, West China Tianfu Hospital Sichuan University  Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,12,26]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtho.2021.11.003"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2021.e06206"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.23048"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.4103\/lungindia.lungindia_284_18"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.2147\/OTT.S296400"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12105-009-0102-9"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.12.9579"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13000-023-01354-4"},{"issue":"11","key":"e_1_2_7_10_1","first-page":"7527","article-title":"Adenoid cystic carcinoma of the tracheobronchial tree: clinicopathologic and immunohistochemical studies of 21 cases","volume":"7","author":"Huo Z","year":"2014","journal-title":"Int J Clin Exp Pathol"},{"issue":"6","key":"e_1_2_7_11_1","first-page":"7619","article-title":"Primary pulmonary adenoid cystic carcinoma: clinicopathological analyses of 12 cases","volume":"8","author":"Qing S","year":"2015","journal-title":"Int J Clin Exp Pathol"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2021.109746"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.21037\/jtd.2018.11.71"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1102\/1470-7330.2006.0013"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lungcan.2021.09.015"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1080\/15384047.2018.1480296"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0025-7125(16)34835-0"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.2147\/CMAR.S182069"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eucr.2019.100927"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijsu.2015.06.084"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clon.2015.06.012"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.5761\/atcs.ed.11.01823"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.4103\/2156-7514.119021"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0169-5002(97)00098-6"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-022-11590-5"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajco.13162"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clon.2017.10.012"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.semdp.2021.03.001"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2018-0515"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41389-020-0194-3"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1097\/JTO.0000000000000656"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13000-015-0409-7"}],"container-title":["Thoracic Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1759-7714.15202","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,14]],"date-time":"2024-02-14T02:06:12Z","timestamp":1707876372000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1759-7714.15202"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12,26]]},"references-count":31,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2024,2]]}},"alternative-id":["10.1111\/1759-7714.15202"],"URL":"https:\/\/doi.org\/10.1111\/1759-7714.15202","archive":["Portico"],"relation":{},"ISSN":["1759-7706","1759-7714"],"issn-type":[{"value":"1759-7706","type":"print"},{"value":"1759-7714","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,12,26]]},"assertion":[{"value":"2023-10-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-12-07","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-12-26","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}