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However, molecular\u2010targeted drugs are known to pass through the blood\u2013brain barrier and present positive effects for central nervous system lesions. There are few reports suggesting how effective molecular\u2010targeted drug therapy alone is for brain metastasis lesions of ALK fusion\u2010positive lung cancer, especially after the first use of ALK\u2010tyrosine kinase inhibitor (TKI) or for bulky brain metastases. A patient in his mid\u2010fifties with stage IV pleural dissemination developed brain metastases after 10\u2009years of crizotinib use, but showed a complete response after switching to brigatinib. Moreover, a patient in her early sixties with stage III recurrent large brain metastases 5\u2009years after chemoradiation therapy experienced dramatic tumor shrinkage with brigatinib. In each case of ALK fusion gene\u2010positive lung cancer with brain metastases, brigatinib showed a high efficacy and was well\u2010tolerated after previous ALK\u2010TKI and for bulky lesions.<\/jats:p>","DOI":"10.1111\/1759-7714.15207","type":"journal-article","created":{"date-parts":[[2023,12,30]],"date-time":"2023-12-30T11:29:12Z","timestamp":1703935752000},"page":"496-499","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["High efficacy of brigatinib for brain metastases in <scp>ALK<\/scp> fusion gene\u2010positive non\u2010small cell lung cancer: A case series"],"prefix":"10.1111","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0745-5118","authenticated-orcid":false,"given":"Kei","family":"Morikawa","sequence":"first","affiliation":[{"name":"Division of Respiratory Diseases, Department of Internal Medicine St. Marianna University School of Medicine  Kawasaki 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