{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T08:52:19Z","timestamp":1769935939159,"version":"3.49.0"},"reference-count":18,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,1,3]],"date-time":"2024-01-03T00:00:00Z","timestamp":1704240000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005006","name":"Asan Institute for Life Sciences, Asan Medical Center","doi-asserted-by":"publisher","award":["2017\u2010689"],"award-info":[{"award-number":["2017\u2010689"]}],"id":[{"id":"10.13039\/501100005006","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Thoracic Cancer"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>About 3%\u20135% of non\u2010small cell lung cancer (NSCLC) presents positive anaplastic lymphoma kinase (ALK). Recently, several target agents have been approved as a treatment for ALK\u2010positive NSCLC. This study aimed to analyze the real\u2010world efficacy and outcome when administered crizotinib, the first approved target agent for ALK\u2010positive NSCLC, according to first\u2010 or late\u2010line treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 290 patients with ALK\u2010positive advanced NSCLC who were treated with crizotinib in 15 institutions in South Korea from January 2009 to December 2018 were enrolled.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The median age of patients was 57.0\u2009years, and 50.3% were male. The median follow\u2010up duration was 29.3\u2009months. Among them, 113 patients received crizotinib as first\u2010line therapy. The objective response rate (ORR) was 60.1% (57.0% for first\u2010line recipients, 61.8% for second\u2212\/later\u2010line). Median (95% CI) progression\u2010free survival (PFS) was 13.7 (11.6\u201317.0) months. For first\u2010line recipients, overall survival (OS) was 26.3 (17.6\u201335.0) months. No significant difference in ORR, PFS and OS, according to the setting of crizotinib initiation, was observed. In a multivariate Cox regression analysis, old age, male gender, initially metastatic, and number of metastatic organs were associated with poor PFS and OS. The most common adverse events were nausea and vomiting, and severe adverse event leading to dose adjustment was hepatotoxicity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>ORR, PFS, OS, and adverse event profiles were comparable to previous clinical trials. Our findings could aid in the efficient management of ALK\u2010positive lung cancer patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1759-7714.15213","type":"journal-article","created":{"date-parts":[[2024,1,4]],"date-time":"2024-01-04T01:29:41Z","timestamp":1704331781000},"page":"448-457","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Real\u2010world outcome of crizotinib for anaplastic lymphoma kinase\u2010positive lung cancer: Multicenter retrospective analysis in South Korea"],"prefix":"10.1111","volume":"15","author":[{"given":"Da Som","family":"Jeon","sequence":"first","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine Nowon Eulji Medical Center, University of Eulji  Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheol\u2010kyu","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine Chonnam National University Hwasun hospital, Chonnam National University  Jeollanam\u2010do Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4836-8958","authenticated-orcid":false,"given":"Seung Joon","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Postech\u2010Catholic Biomedical Engineering Institute, College of Medicine, The Catholic University of Korea  Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4107-444X","authenticated-orcid":false,"given":"Chan Kwon","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine Catholic University of Korean Yeouido Saint Mary's Hospital  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoon Soo","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Yonsei University College of Medicine, 8th Floor Annex Building, Yongdong Severance Hospital  Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chi Young","family":"Jung","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Daegu Catholic University School of Medicine  Daegu Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8693-5792","authenticated-orcid":false,"given":"Sung Yong","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Internal Medicine, Korea University Guro Hospital, Korea University College of Medicine  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2121-7335","authenticated-orcid":false,"given":"Shin\u2010Yup","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine Kyungpook National University Chilgok Hospital  Daegu Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeong\u2010Seon","family":"Ryu","sequence":"additional","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine Inha University Hospital  Incheon Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6173-2748","authenticated-orcid":false,"given":"Jeong Eun","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Chungnam National University Hospital  Daejeon Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kye Young","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine Konkuk University School of Medicine  Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tae Won","family":"Jang","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Kosin University Medical College  Pusan Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seung Hun","family":"Jang","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Allergy and Critical Care Medicine, Hallym University Sacred Heart Hospital  Anyang Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seong Hoon","family":"Yoon","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine School of Medicine, Pusan National University  Yangsan Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sang Hoon","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Pulmonology, Institute of Chest Disease, Department of Internal Medicine Yonsei University College of Medicine  Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2881-4669","authenticated-orcid":false,"given":"Chang\u2010min","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine Asan Medical Centre, University of Ulsan College of Medicine  Seoul Republic of Korea"},{"name":"Department of Oncology Asan Medical Centre, University of Ulsan College of Medicine  Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyeong Ryul","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine Asan Medical Centre, University of Ulsan College of Medicine  Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0116-7681","authenticated-orcid":false,"given":"Yeon Joo","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of 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