{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T14:37:10Z","timestamp":1785508630805,"version":"3.56.0"},"reference-count":33,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2024,1,31]],"date-time":"2024-01-31T00:00:00Z","timestamp":1706659200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007452","name":"Wu Jieping Medical Foundation","doi-asserted-by":"publisher","award":["320.6750.19094.29"],"award-info":[{"award-number":["320.6750.19094.29"]}],"id":[{"id":"10.13039\/100007452","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Thoracic Cancer"],"published-print":{"date-parts":[[2024,3]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>Neutrophil\u2010to\u2010lymphocyte ratio (NLR<\/jats:styled-content>) and platelet\u2010to\u2010lymphocyte ratio (PLR<\/jats:styled-content>) are closely related to the prognosis of patients with non\u2010small cell lung cancer, but their effect on extensive\u2010stage small cell lung cancer (ES\u2010SCLC<\/jats:styled-content>) remains uncertain.<\/jats:p><\/jats:sec>Methods<\/jats:title>This retrospective study was conducted in ES\u2010SCLC patients treated with first\u2010line atezolizumab or durvalumab and platinum\u2010etoposide. Clinical data from three hospitals were analyzed. Significant risk factors for survival were identified using descriptive statistics and Cox<\/jats:styled-content> regression. Homogeneity was assessed using t<\/jats:italic>\u2010tests or nonparametric tests. Kaplan\u2010Meier<\/jats:styled-content> analysis revealed an association between high NLR<\/jats:styled-content> level and median PFS<\/jats:styled-content> and OS<\/jats:styled-content>.<\/jats:p><\/jats:sec>Results<\/jats:title>A total of 300 ES\u2010SCLC<\/jats:styled-content> patients were included in the study. Cox<\/jats:styled-content> regression analysis revealed that an elevated NLR<\/jats:styled-content> level after the second treatment cycle (defined as NLRT2<\/jats:styled-content>) was an independent prognostic factor for survival. Stratifying patients based on median NLRT2<\/jats:styled-content> showed significant differences in both PFS<\/jats:styled-content> (HR<\/jats:styled-content>: 1.863, 95% CI<\/jats:styled-content>: 1.62\u20132.12, p<\/jats:italic> <\u20090.001) and OS<\/jats:styled-content> (HR<\/jats:styled-content>: 2.581, 95% CI<\/jats:styled-content>: 2.19\u20133.04, p<\/jats:italic> <\u20090.001) between NLR<\/jats:styled-content> \u2265\u20091.75 and NLR<\/jats:styled-content> <\u20091.75 groups. mPFS<\/jats:styled-content> and mOS<\/jats:styled-content> were 8.2 versus 6.1 months and 13.7 versus 9.5 months, respectively. NLR<\/jats:styled-content> was also associated with treatment efficacy and occurrence of irAEs<\/jats:styled-content>. Further stratification based on NLR<\/jats:styled-content> and irAEs<\/jats:styled-content> showed that in the NLR<\/jats:styled-content> <\u20091.75 group, patients with irAEs<\/jats:styled-content> had prolonged mPFS<\/jats:styled-content> and mOS<\/jats:styled-content>. In the NLR<\/jats:styled-content> \u2265\u20091.75 group, only mPFS<\/jats:styled-content> showed a significant difference between patients with and without irAEs<\/jats:styled-content>.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>NLRT2<\/jats:styled-content> and irAEs<\/jats:styled-content> can predict the prognosis of ES\u2010SCLC<\/jats:styled-content> patients with first\u2010line ES\u2010SCLC<\/jats:styled-content> receiving PD\u2010L1<\/jats:styled-content> inhibitors combined with chemotherapy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1759-7714.15225","type":"journal-article","created":{"date-parts":[[2024,1,31]],"date-time":"2024-01-31T14:25:46Z","timestamp":1706711146000},"page":"559-569","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Prognostic implications of neutrophil\u2010to\u2010lymphocyte ratio in patients with extensive\u2010stage small cell lung cancer receiving chemoimmunotherapy: A multicenter, real\u2010world study"],"prefix":"10.1111","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9899-8774","authenticated-orcid":false,"given":"Huanhuan","family":"Bi","sequence":"first","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine the Affiliated Hospital of Qingdao University Qingdao China"},{"name":"Department of Respiratory and Critical Care Medicine The Affiliated Qingdao Central Hospital of Medical College of Qingdao University Qingdao China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dunqiang","family":"Ren","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine the Affiliated Hospital of Qingdao University Qingdao China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuting","family":"Xiao","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine the Affiliated Hospital of Qingdao University Qingdao China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinxue","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine the Affiliated Hospital of Qingdao University Qingdao China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bingqian","family":"Yi","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine the Affiliated Hospital of Qingdao University Qingdao China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weizhong","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine the Affiliated Hospital of Qingdao University Qingdao China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanmei","family":"Shao","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine the Affiliated Hospital of Qingdao University Qingdao 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