{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,6]],"date-time":"2025-12-06T05:06:30Z","timestamp":1764997590369,"version":"3.40.5"},"reference-count":21,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2024,2,7]],"date-time":"2024-02-07T00:00:00Z","timestamp":1707264000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004735","name":"Natural Science Foundation of Hunan Province","doi-asserted-by":"publisher","award":["2021RC4040","2023JJ30371","2023JJ30368"],"award-info":[{"award-number":["2021RC4040","2023JJ30371","2023JJ30368"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Thoracic Cancer"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Pericardial synovial sarcomas (PSS) have a low incidence rate and are highly invasive with a dismal prognosis. Standard treatment includes surgery, radiotherapy and chemotherapy but with limited response. Here, we report the case of a 15\u2010year\u2010old nonsmoking youngster diagnosed with PSS who developed disease relapsed from surgery after 1\u2009month. Next\u2010generation sequencing (NGS) using baseline tissue was performed, and BRCA2 c.968dupT was detected. Then pazopanib (a multitargeted inhibitor) plus nivolumab (an immune checkpoint inhibitor) was administered, with a partial response and progression\u2010free survival of 14\u2009months. BRCA2 c.968dupT has not previously been reported in PSS and its response to targeted combination immunotherapy are not well characterized. Here, we report the efficacy of pazopanib combined with nivolumab in a PSS patient harboring BRCA2 c.968dupT and also provide the clinical evidence of the utility of NGS in exploring actionable mutations for solid tumor. Combination therapy based on immunotherapy may be a potential treatment choice for PSS harboring BRCA2 mutation.<\/jats:p>","DOI":"10.1111\/1759-7714.15237","type":"journal-article","created":{"date-parts":[[2024,2,7]],"date-time":"2024-02-07T10:09:28Z","timestamp":1707300568000},"page":"667-671","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Remarkable response to pazopanib plus vivolumab in a patient with pericardial synovial sarcoma carrying a novel genotype <scp>BRCA2<\/scp> c.<scp>968dupT: A case report<\/scp>"],"prefix":"10.1111","volume":"15","author":[{"given":"Xing","family":"Zhang","sequence":"first","affiliation":[{"name":"Graduate Collaborative Training Base of Hunan Cancer Hospital, Hengyang Medical School University of South China  Hengyang Hunan China"},{"name":"Lung Cancer and Gastrointestinal Unit, Hunan Cancer Hospital, Department of Medical Oncology The Affiliated Cancer Hospital of Xiangya School of Medicine  Changsha Hunan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qinqin","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Qinghai Provincial People's Hospital  Xining Qinghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6829-7176","authenticated-orcid":false,"given":"Yongchang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Graduate Collaborative Training Base of Hunan Cancer Hospital, Hengyang Medical School University of South China  Hengyang Hunan China"},{"name":"Lung Cancer and Gastrointestinal Unit, Hunan Cancer Hospital, Department of Medical Oncology The Affiliated Cancer Hospital of Xiangya School of Medicine  Changsha Hunan 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