{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T13:11:06Z","timestamp":1767705066076,"version":"3.40.5"},"reference-count":22,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Thoracic Cancer"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Consolidative thoracic radiotherapy (cTRT) has previously shown benefit to patients with extensive stage small cell lung cancer (ES\u2010SCLC) who respond to chemotherapy. However, the optimum dose of cTRT is unknown. The purpose of this randomized trial is to compare the efficacy of 45\u2009Gy in 15 fractions with 30\u2009Gy in 10 fractions cTRT in ES\u2010SCLC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This phase III, multicenter, randomized trial is designed to evaluate the safety and efficacy of different cTRT dose in ES\u2010SCLC. Eligible patients with pathologically confirmed ES\u2010SCLC who responded to 4\u20136\u2009cycles of etoposide plus cisplatin (EP) or carboplatin (EC) chemotherapy were randomized 1:1 to receive either 30 Gy in 10 fractions (standard dose) or 45 Gy in 15 fractions (high dose) cTRT. The primary endpoint is 2\u2010year overall survival (OS). Secondary endpoints include 2\u2010year progression\u2010free survival (PFS), 2\u2010year local control (LC) and treatment related toxicity as measured by adverse events according to the Common Terminology Criteria for Adverse Events (version 4.0).<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>The present study is the first randomized phase III trial designed to evaluate the efficacy of higher versus lower dose cTRT in ES\u2010SCLC, providing evidence for future clinical practice in prolonging survival of patients with ES\u2010SCLC.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1759-7714.15263","type":"journal-article","created":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T09:05:21Z","timestamp":1709283921000},"page":"938-943","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Phase <scp>III,<\/scp> multicenter, randomized trial of 45\u2009<scp>Gy<\/scp> versus 30\u2009<scp>Gy<\/scp> thoracic radiation for extensive\u2010stage small cell lung cancer (<scp>ES\u2010SCLC<\/scp>): Study protocol"],"prefix":"10.1111","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5919-5074","authenticated-orcid":false,"given":"Lei","family":"Deng","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology, National Cancer Center\/National Clinical Research Center for Cancer\/Cancer Hospital Chinese Academy of Medical Science and Peking Union Medical College  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-8612-5391","authenticated-orcid":false,"given":"Gulidanna","family":"Shayan","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, National Cancer Center\/National Clinical Research Center for Cancer\/Cancer Hospital Chinese Academy of Medical Science and Peking Union Medical College  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, National Cancer Center\/Cancer Hospital and Shenzhen Hospital Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nan","family":"Bi","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, National Cancer Center\/National Clinical Research Center for Cancer\/Cancer Hospital Chinese Academy of Medical Science and Peking Union Medical College  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5272-1681","authenticated-orcid":false,"given":"Luhua","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, National Cancer Center\/Cancer Hospital and Shenzhen Hospital Chinese Academy of Medical 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