{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T08:47:06Z","timestamp":1776329226651,"version":"3.50.1"},"reference-count":34,"publisher":"Wiley","issue":"15","license":[{"start":{"date-parts":[[2024,4,16]],"date-time":"2024-04-16T00:00:00Z","timestamp":1713225600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004340","name":"Siemens","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004340","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004334","name":"Merck","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004334","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001127","name":"Genentech Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001127","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004337","name":"Roche","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004337","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100019450","name":"Verastem Oncology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100019450","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Thoracic Cancer"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Tumor recurrence remains the main barrier to survival after surgery for pleural mesothelioma (PM). Soluble mesothelin\u2010related protein (SMRP) and cancer antigen 125 (CA\u2010125) are established blood\u2010based biomarkers for monitoring PM. We prospectively studied the utility of these biomarkers after pleurectomy decortication (PD).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients who underwent PD and achieved complete macroscopic resection with available preoperative SMRP levels were included. Tumor marker levels were determined within 60\u2009days of three timepoints: (1) preoperation, (2) post\u2010operation, and (3) recurrence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 356 evaluable patients, 276 (78%) had recurrence by the end of follow\u2010up interval. Elevated preoperative SMRP levels were associated with epithelioid histology (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.013), advanced TNM (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) stage, and clinical stage (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Preoperative CA\u2010125 levels were not significantly associated with clinical covariates. Neither biomarker was associated with survival or disease\u2010free survival. With respect to nonpleural and nonlymphatic recurrences, mean SMRP levels were elevated in patients with pleural (<jats:italic>p<\/jats:italic>\u2009=\u20090.021) and lymph node (<jats:italic>p<\/jats:italic>\u2009=\u20090.042) recurrences. CA\u2010125 levels were significantly higher in patients with abdominal (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) and lymph node (<jats:italic>p<\/jats:italic>\u2009=\u20090.004) recurrences. Among patients with all three timepoints available, we observed an average decrease in SMRP levels by 1.93\u2009nmol\/L (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) postoperatively and again an average increase at recurrence by 0.79\u2009nmol\/L (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). There were no significant changes in levels of CA\u2010125 across the study timepoints (<jats:italic>p<\/jats:italic>\u2009=\u20090.47).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Longitudinal changes in SMRP levels corresponded with a radiographic presence of disease in a subset of patients. SMRP surveillance could aid in detection of local recurrences, whereas CA\u2010125 could be helpful in recognizing abdominal recurrences.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1759-7714.15264","type":"journal-article","created":{"date-parts":[[2024,4,17]],"date-time":"2024-04-17T04:41:52Z","timestamp":1713328912000},"page":"1237-1245","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Circulating <scp>SMRP<\/scp> and <scp>CA<\/scp>\u2010125 before and after pleurectomy decortication for pleural mesothelioma"],"prefix":"10.1111","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4364-2201","authenticated-orcid":false,"given":"Juuso","family":"Paajanen","sequence":"first","affiliation":[{"name":"The Thoracic Surgery Oncology Laboratory and the International Mesothelioma Program (http:\/\/www.impmeso.org), Division of Thoracic Surgery and the Lung Center, Brigham, and Women's Hospital Harvard Medical School  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmed","family":"Sadek","sequence":"additional","affiliation":[{"name":"The Thoracic Surgery Oncology Laboratory and the International Mesothelioma Program (http:\/\/www.impmeso.org), Division of Thoracic Surgery and the Lung Center, Brigham, and Women's Hospital Harvard Medical School  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William G.","family":"Richards","sequence":"additional","affiliation":[{"name":"The Thoracic Surgery Oncology Laboratory and the International Mesothelioma Program (http:\/\/www.impmeso.org), Division of Thoracic Surgery and the Lung Center, Brigham, and Women's Hospital Harvard Medical School  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yue","family":"Xie","sequence":"additional","affiliation":[{"name":"Deparment of Data Science Dana\u2010Farber Cancer Institute  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emanuele","family":"Mazzola","sequence":"additional","affiliation":[{"name":"Deparment of Data Science Dana\u2010Farber Cancer Institute  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristina","family":"Sidopoulos","sequence":"additional","affiliation":[{"name":"The Thoracic Surgery Oncology Laboratory and the International Mesothelioma Program (http:\/\/www.impmeso.org), Division of Thoracic Surgery and the Lung Center, Brigham, and Women's Hospital Harvard Medical School  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Kuckelman","sequence":"additional","affiliation":[{"name":"The Thoracic Surgery Oncology Laboratory and the International Mesothelioma Program (http:\/\/www.impmeso.org), Division of Thoracic Surgery and the Lung Center, Brigham, and Women's Hospital Harvard Medical School  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ritu R.","family":"Gill","sequence":"additional","affiliation":[{"name":"Department of Radiology Beth Israel Deaconess Medical Center and Harvard Medical School  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raphael","family":"Bueno","sequence":"additional","affiliation":[{"name":"The Thoracic Surgery Oncology Laboratory and the International Mesothelioma Program (http:\/\/www.impmeso.org), Division of Thoracic Surgery and the Lung Center, Brigham, and Women's Hospital Harvard Medical School  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,4,16]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.32931"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0145039"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/s1556-0864(15)31536-7"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000004306"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2014.10.041"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2016.08.071"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200311000-00003"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-10-1929"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2006.079327"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004347-198303000-00005"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/1476-4598-13-129"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1245\/aso.2003.05.015"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.4137\/bmi.s3927"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-006-9192-8"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-003-1851-6"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2014-205205"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.39.6671"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2015.286"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40064-016-1998-7"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/jso.27152"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-40618-3"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djx175"},{"key":"e_1_2_8_24_1","volume-title":"R: a language and environment for statistical computing","author":"R Core Team","year":"2020"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.17436"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2017.06.042"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.07-0013"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-4975(96)01228-3"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2014.10.128"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1080\/00365513.2023.2168213"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-06-2144"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2009.26.9944"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.21037\/jtd-20-1910"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2407-14-674"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2007.07.042"}],"container-title":["Thoracic Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1759-7714.15264","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,27]],"date-time":"2024-05-27T01:50:46Z","timestamp":1716774646000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1759-7714.15264"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,16]]},"references-count":34,"journal-issue":{"issue":"15","published-print":{"date-parts":[[2024,5]]}},"alternative-id":["10.1111\/1759-7714.15264"],"URL":"https:\/\/doi.org\/10.1111\/1759-7714.15264","archive":["Portico"],"relation":{},"ISSN":["1759-7706","1759-7714"],"issn-type":[{"value":"1759-7706","type":"print"},{"value":"1759-7714","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,4,16]]},"assertion":[{"value":"2023-12-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-02-07","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-04-16","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}