{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T17:13:04Z","timestamp":1782493984929,"version":"3.54.5"},"reference-count":19,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2024,2,27]],"date-time":"2024-02-27T00:00:00Z","timestamp":1708992000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["23K08288"],"award-info":[{"award-number":["23K08288"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["22K08996"],"award-info":[{"award-number":["22K08996"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["21K07233"],"award-info":[{"award-number":["21K07233"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Thoracic Cancer"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Regional lymph node recurrence after radical surgery for non\u2010small cell lung cancer (NSCLC) is an oligo\u2010recurrent disease; however, no treatment strategy has been established. In the present study we aimed to determine the clinical outcomes of postoperative regional lymph node recurrence and identify prognostic predictors in the era of molecular\u2010targeted therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively analyzed data on clinical characteristics and outcomes of patients with regional lymph node recurrence after surgery who underwent treatment for NSCLC between 2002 and 2022.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 53 patients were included in this study. The median time between surgery and detection of recurrence was 1.21\u2009years. Radiotherapy (RT) alone and chemoradiotherapy (CRT) were performed in 38 and six patients, respectively. Driver gene alterations were detected in eight patients (EGFR: 6, ROS1:1, and BRAF: 1) and programmed death\u2010ligand 1 (PD\u2010L1) expression was examined in 22 patients after 2016. Median progression\u2010free survival (PFS) and overall survival (OS) after lymph node recurrences were 1.32 and 4.34\u2009years, respectively. Multiple lymph node recurrence was an independent prognostic factor for PFS, whereas driver gene alteration was the only prognostic factor for OS. There was no significant difference in the OS between patients stratified according to the initial treatment modality for lymph node recurrence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our results suggest that the number of tumor recurrences may correlate with PFS, while detection of driver gene alterations could guide decision\u2010making for the appropriate molecular\u2010targeted therapy to achieve longer OS.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1759-7714.15265","type":"journal-article","created":{"date-parts":[[2024,2,28]],"date-time":"2024-02-28T07:38:29Z","timestamp":1709105909000},"page":"859-866","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Prognosis of non\u2010small cell lung cancer with postoperative regional lymph node recurrence"],"prefix":"10.1111","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5485-3234","authenticated-orcid":false,"given":"Yoichi","family":"Ohtaki","sequence":"first","affiliation":[{"name":"Department of General Surgical Science, Gunma University Graduate School of Medicine, Division of General Thoracic Surgery Integrative Center of General Surgery, Gunma University Hospital  Maebashi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiteru","family":"Nagashima","sequence":"additional","affiliation":[{"name":"Department of General Surgical Science, Gunma University Graduate School of Medicine, Division of General Thoracic Surgery Integrative Center of General Surgery, Gunma University Hospital  Maebashi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoko","family":"Okano","sequence":"additional","affiliation":[{"name":"Gunma University Heavy Ion Medical Center  Maebashi 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Medicine, Gunma University Hospital  Maebashi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yosuke","family":"Miura","sequence":"additional","affiliation":[{"name":"Division of Allergy and Respiratory Medicine Integrative Center of Internal Medicine, Gunma University Hospital  Maebashi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seshiru","family":"Nakazawa","sequence":"additional","affiliation":[{"name":"Department of General Surgical Science, Gunma University Graduate School of Medicine, Division of General Thoracic Surgery Integrative Center of General Surgery, Gunma University Hospital  Maebashi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natsuko","family":"Kawatani","sequence":"additional","affiliation":[{"name":"Department of General Surgical Science, Gunma University Graduate School of Medicine, Division of General Thoracic Surgery Integrative Center of General Surgery, Gunma University Hospital  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Surgery, Gunma University Hospital  Maebashi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ken","family":"Shirabe","sequence":"additional","affiliation":[{"name":"Department of General Surgical Science, Gunma University Graduate School of Medicine, Division of General Thoracic Surgery Integrative Center of General Surgery, Gunma University Hospital  Maebashi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,2,27]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/JTO.0b013e3182a5097b"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cllc.2012.05.008"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cllc.2012.11.002"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cllc.2014.06.001"},{"key":"e_1_2_9_6_1","first-page":"333","article-title":"Comparison of the efficacy of radiotherapy between postoperative 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