{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T00:05:36Z","timestamp":1784333136407,"version":"3.55.0"},"reference-count":24,"publisher":"Wiley","issue":"13","license":[{"start":{"date-parts":[[2024,3,26]],"date-time":"2024-03-26T00:00:00Z","timestamp":1711411200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81773144"],"award-info":[{"award-number":["81773144"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Thoracic Cancer"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The aim of the study was to evaluate the prognostic value of postoperative folate receptor\u2010positive\u2009circulating tumor cell (FR\u2009+\u2009CTC) detection in patients with stage I\u2013III invasive adenocarcinoma (IAC) treated with surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients with lung adenocarcinoma (LUAD) who underwent surgical resection in Peking University Cancer Hospital and received postoperative FR\u2009+\u2009CTC analysis from July 2016 to January 2021 were retrospectively collected. Comparisons between or among groups were made using the Kruskal\u2010Wallis or Mann\u2013Whitney U tests. Survival curves were estimated using the Kaplan\u2013Meier method and compared using the log\u2010rank test. Cox proportional hazard regression analyses were performed to explore the factors predicting recurrence and survival.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were significant differences between the high and low groups in terms of age (<jats:italic>p<\/jats:italic>\u2009=\u20090.002), postoperative CA199 (<jats:italic>p<\/jats:italic>\u2009=\u20090.038), and postoperative SCC (<jats:italic>p<\/jats:italic>\u2009=\u20090.024). There were no significant differences in the other indicators (all <jats:italic>p<\/jats:italic>&gt;0.05). N stage 1, N stage 2, and neoadjuvant therapy (NAT) were independent risk factors for disease recurrence and death; pleural invasion (PI), and nerve invasion were independent risk factors for death. The Kaplan\u2013Meier curve showed a notable trend for a worse disease\u2010free survival (DFS) or overall survival (OS) for patients with high levels of FR\u2009+\u2009CTCs in our study, but none of these were statistically significant.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The detection of FR\u2009+\u2009CTCs postoperatively was an independent predictor of recurrence in patients treated for stage I\u2013III IAC. Standardized detection methods and optimal time points for assessment should be established in future studies.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1759-7714.15288","type":"journal-article","created":{"date-parts":[[2024,3,27]],"date-time":"2024-03-27T05:40:20Z","timestamp":1711518020000},"page":"1060-1071","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Clinical significance of postoperative folate receptor\u2010positive circulating tumor cells (<scp>FR<\/scp>\u2009+\u2009<scp>CTCs)<\/scp> for long\u2010term prognosis in patients with invasive adenocarcinoma (<scp>IAC<\/scp>) of the lung"],"prefix":"10.1111","volume":"15","author":[{"given":"Zeming","family":"Ma","sequence":"first","affiliation":[{"name":"Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education\/Beijing), Department of Thoracic Surgery II Peking University Cancer Hospital &amp; Institute  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiwei","family":"Zhou","sequence":"additional","affiliation":[{"name":"Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education\/Beijing), Department of Thoracic Surgery II Peking University Cancer Hospital &amp; Institute  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shijie","family":"Wang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education\/Beijing), Department of Thoracic Surgery II Peking University Cancer Hospital &amp; Institute  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Ji","sequence":"additional","affiliation":[{"name":"Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education\/Beijing), Department of Thoracic Surgery II Peking University Cancer Hospital &amp; Institute  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dachuan","family":"Zhao","sequence":"additional","affiliation":[{"name":"Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education\/Beijing), Department of Thoracic Surgery II Peking University Cancer Hospital &amp; Institute  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Wang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education\/Beijing), Department of Thoracic Surgery II Peking University Cancer Hospital &amp; Institute  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4574-8202","authenticated-orcid":false,"given":"Jinfeng","family":"Chen","sequence":"additional","affiliation":[{"name":"Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education\/Beijing), Department of Thoracic Surgery II Peking University Cancer Hospital &amp; Institute  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,3,26]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21660"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/10732748221084930"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjms.2020.09.014"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.21037\/tlcr.2016.06.07"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2020.06.066"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.24625"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers15235679"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.21037\/jtd.2017.03.130"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arbres.2023.12.001"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.21037\/tlcr.2016.10.07"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3007094"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-20-1311"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1593\/tlo.13535"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/JTO.0000000000000606"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamasurg.2019.0972"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.21037\/tlcr-21-149"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.21037\/jtd-20-1636"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000005708"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.21037\/tlcr-22-827"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtho.2015.09.009"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1109\/TAC.1974.1100705"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-008-9961-7"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-18-0432"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-18-0120"}],"container-title":["Thoracic Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1759-7714.15288","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,2]],"date-time":"2024-05-02T01:25:34Z","timestamp":1714613134000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1759-7714.15288"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,26]]},"references-count":24,"journal-issue":{"issue":"13","published-print":{"date-parts":[[2024,5]]}},"alternative-id":["10.1111\/1759-7714.15288"],"URL":"https:\/\/doi.org\/10.1111\/1759-7714.15288","archive":["Portico"],"relation":{},"ISSN":["1759-7706","1759-7714"],"issn-type":[{"value":"1759-7706","type":"print"},{"value":"1759-7714","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,3,26]]},"assertion":[{"value":"2024-02-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-03-07","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-03-26","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}