{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T01:21:30Z","timestamp":1792027290261,"version":"4.4.0"},"reference-count":26,"publisher":"Wiley","issue":"15","license":[{"start":{"date-parts":[[2024,4,15]],"date-time":"2024-04-15T00:00:00Z","timestamp":1713139200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Thoracic Cancer"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>There have been reports on the impact of concurrent drugs on the outcome of immunotherapy for non\u2010small cell lung carcinoma (NSCLC). However, the effect of some drugs, such as antibiotics and nonsteroidal anti\u2010inflammatory drugs (NSAIDs), has not been clarified in patients with NSCLC. In the present study, we aimed to assess the association between concurrent drugs and the outcomes of immune checkpoint inhibitors (ICIs) alone or in combination with chemotherapy for patients with advanced NSCLC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We retrospectively assessed patients with advanced NSCLC who underwent ICI treatment between September 2017 and December 2021 at Kobe University Hospital. We evaluated the data regarding the use of antibiotics within 30\u2009days before ICI initiation, as well as the use of proton pump inhibitors (PPIs) and NSAIDs during ICI initiation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 127 patients were assessed, among whom 28 (22.0%) patients received antibiotics, 39 (30.7%) PPIs, and 36 (28.3%) NSAIDs. No significant differences were observed between the patients with and without antibiotic use. However, patients using NSAIDs had significantly worse objective response rates (ORR) and progression\u2010free survival (PFS) with ICI alone or in combination with chemotherapy compared to those who did not (ORR, 47.2% vs. 67.0%;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.045. PFS, 6.3\u2009months vs. 10.8\u2009months;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.02). Patients using PPIs demonstrated a worse ORR of ICI in combination with chemotherapy compared to those who did not (ORR, 45.2% vs. 72.6%;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.013).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The unnecessary use of NSAIDs along with immunotherapy should be discouraged.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/1759-7714.15294","type":"journal-article","created":{"date-parts":[[2024,4,16]],"date-time":"2024-04-16T01:43:56Z","timestamp":1713231836000},"page":"1228-1236","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Impact of concurrent medications on the outcome of immunotherapy in non\u2010small cell lung carcinoma"],"prefix":"10.1111","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7595-5843","authenticated-orcid":false,"given":"Jun","family":"Yamada","sequence":"first","affiliation":[{"name":"Division of Respiratory Medicine, Department of Internal Medicine Kobe University Graduate School of Medicine  Kobe Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takafumi","family":"Fukui","sequence":"additional","affiliation":[{"name":"Division of Respiratory Medicine, Department of Internal Medicine Kobe University Graduate School of Medicine  Kobe Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsuhiko","family":"Yatani","sequence":"additional","affiliation":[{"name":"Division of Respiratory Medicine, Department of Internal Medicine Kobe University Graduate School of Medicine  Kobe Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9940-3659","authenticated-orcid":false,"given":"Chihiro","family":"Mimura","sequence":"additional","affiliation":[{"name":"Division of Respiratory Medicine, Department of Internal Medicine Kobe University Graduate School of Medicine  Kobe Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiyoko","family":"Fukuda","sequence":"additional","affiliation":[{"name":"Division of Respiratory Medicine, Department of Internal Medicine Kobe University Graduate School of Medicine  Kobe Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daisuke","family":"Hazama","sequence":"additional","affiliation":[{"name":"Division of Respiratory Medicine, Department of Internal Medicine Kobe University Graduate School of Medicine  Kobe Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoko","family":"Katsurada","sequence":"additional","affiliation":[{"name":"Division of Respiratory Medicine, Department of Internal Medicine Kobe University Graduate School of Medicine  Kobe Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatsuya","family":"Nagano","sequence":"additional","affiliation":[{"name":"Division of Respiratory Medicine, Department of Internal Medicine Kobe University Graduate School of Medicine  Kobe Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0596-555X","authenticated-orcid":false,"given":"Masatsugu","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Division of Respiratory Medicine, Department of Internal Medicine Kobe University Graduate School of Medicine  Kobe Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4598-220X","authenticated-orcid":false,"given":"Motoko","family":"Tachihara","sequence":"additional","affiliation":[{"name":"Division of Respiratory Medicine, Department of Internal Medicine Kobe University Graduate School of Medicine  Kobe 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