{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T14:00:49Z","timestamp":1780581649763,"version":"3.54.1"},"reference-count":22,"publisher":"Wiley","issue":"15","license":[{"start":{"date-parts":[[2024,4,12]],"date-time":"2024-04-12T00:00:00Z","timestamp":1712880000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Thoracic Cancer"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The surgical outcomes for younger patients with non\u2010small cell lung cancer (NSCLC) remain uncertain. The aim of this study was to investigate the clinical features long\u2010term survival outcomes in younger individuals with NSCLC following surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We queried the Surveillance, Epidemiology, and End Results database from 2010 to 2017, selecting all pathologically confirmed NSCLC cases that underwent cancer\u2010directed surgery. Younger patients were defined as those aged 18\u201350\u2009years, while older patients were 51\u201380\u2009years. Propensity score matching (PSM) was implemented to mitigate selection bias. Overall survival (OS) and lung cancer\u2010specific survival (LCSS) were compared using the Kaplan\u2013Meier method.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among the 33\u2009586 treated surgically patients, 2223 (6.6%) were young. Compared to the older group, younger patients had a higher frequency of female gender, non\u2010white ethnicity, carcinoid tumors, stage IV disease, pneumonectomy, and postoperative adjuvant therapies. The 5\u2010year OS rates were significantly higher for younger patients (79.3% vs. 62.0%; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), as were the 5\u2010year LCSS rates (82.4% vs. 71.8%; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Post\u2010PSM, younger patients consistently demonstrated significantly better OS and LCSS. Further stage\u2010specific analysis revealed significantly improved 5\u2010year OS rates at each stage and superior 5\u2010year LCSS for stages I\u2013II among younger patients. However, there was no statistically significant difference in LCSS for stages III\u2013IV.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Overall, younger patients with NSCLC treated surgically exhibit superior OS and LCSS compared to their older counterparts, although no statistically significant difference in LCSS for stages III\u2013IV was observed between the two age groups.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1759-7714.15300","type":"journal-article","created":{"date-parts":[[2024,4,12]],"date-time":"2024-04-12T11:43:20Z","timestamp":1712922200000},"page":"1218-1227","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Surgical outcomes for non\u2010small cell lung cancer in younger adults: A population\u2010based study"],"prefix":"10.1111","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0741-6837","authenticated-orcid":false,"given":"Zhirong","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Thoracic Surgery Beijing Institute of Respiratory Medicine and Beijing Chao\u2010Yang Hospital, Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huandong","family":"Huo","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery National Cancer Center\/National Clinical Research Center for Cancer\/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Surgery The Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital), Institute of Basic Medicine and Cancer (IBMC), Chinese Academy of Sciences  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinbai","family":"Miao","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery Beijing Institute of Respiratory Medicine and Beijing Chao\u2010Yang Hospital, Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery Beijing Institute of Respiratory Medicine and Beijing Chao\u2010Yang Hospital, Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuo","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery Beijing Institute of Respiratory Medicine and Beijing Chao\u2010Yang Hospital, Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,4,12]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21660"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21763"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2023.28171"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(21)00581-7"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lungcan.2013.11.007"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.21037\/tlcr-22-443"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-4975(92)91150-8"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1994.12.5.981"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2008.01.031"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.21037\/atm.2019.03.39"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.120.1.32"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1177\/021849230801600509"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-4975(96)00745-X"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hlc.2014.07.054"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2021.12.655"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.32809"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1715907"},{"key":"e_1_2_9_19_1","first-page":"990","article-title":"Incidence 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