{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T23:56:39Z","timestamp":1786665399725,"version":"build-2736575974"},"reference-count":42,"publisher":"Wiley","issue":"19","license":[{"start":{"date-parts":[[2024,5,27]],"date-time":"2024-05-27T00:00:00Z","timestamp":1716768000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Thoracic Cancer"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Malignant mesothelioma (MM) is an exceedingly rare tumor with poor prognosis due to the limited availability of effective treatment. Immunotherapy has emerged as a novel treatment approach for MM, but less than 40% of the patients benefit from it. Thus, it is necessary to identify accurate and effective biomarkers that can predict the overall survival (OS) and immunotherapy efficacy for MM.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>DNA sequencing was used to identify the genomic landscape based on the data from 86 Chinese patients. T cell receptor (TCR) sequencing was used to characterize MM TCR repertoires of 28 patients between October 2016 and April 2023.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Patients with <jats:italic>TP53<\/jats:italic>, <jats:italic>NF2<\/jats:italic>, or <jats:italic>CDKN2A<\/jats:italic> variants at the genomic level, as well as those exhibiting lower Shannon index (&lt;6.637), lower evenness (&lt;0.028), or higher clonality (\u22650.194) according to baseline tumor tissue TCR indexes, demonstrated poorer OS. Furthermore, patients with <jats:italic>TP53<\/jats:italic>, <jats:italic>CDKN2A<\/jats:italic>, or <jats:italic>CDKN2B<\/jats:italic> variants and those with a lower evenness (&lt;0.030) in baseline tumor tissue showed worse immunotherapy efficacy. The present study is the first to identify five special TCR V\u03b2\u2010J\u03b2 rearrangements associated with MM immunotherapy efficacy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The present study reported the largest\u2010scale genomic landscape and TCR repertoire of MM in Chinese patients and identified genomic and TCR biomarkers for the prognosis and immunotherapy efficacy in MM. The study results might provide new insights for prospective MM trials using specific genes, TCR indexes, and TCR clones as biomarkers and offer a reference for future antitumor drugs based on TCR\u2010specific clones.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1759-7714.15326","type":"journal-article","created":{"date-parts":[[2024,5,27]],"date-time":"2024-05-27T07:44:01Z","timestamp":1716795841000},"page":"1502-1512","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Genomic and T cell repertoire biomarkers associated with malignant mesothelioma survival"],"prefix":"10.1111","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-4992-0303","authenticated-orcid":false,"given":"Muwen","family":"Nie","sequence":"first","affiliation":[{"name":"Department of Medical Oncology, Peking Union Medical College Hospital Chinese Academy of Medical Sciences &amp; Peking Union Medical College  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhao","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Peking Union Medical College Hospital Chinese Academy of Medical Sciences &amp; Peking Union Medical College  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ningning","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Peking Union Medical College Hospital Chinese Academy of Medical Sciences &amp; Peking Union Medical College  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liangrui","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Pathology, Peking Union Medical College Hospital Chinese Academy of Medical Sciences &amp; Peking Union Medical College  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuchun","family":"Wang","sequence":"additional","affiliation":[{"name":"Medical Department Geneplus\u2010Beijing  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5475-7736","authenticated-orcid":false,"given":"Mingming","family":"Yuan","sequence":"additional","affiliation":[{"name":"Medical Department Geneplus\u2010Beijing  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rongrong","family":"Chen","sequence":"additional","affiliation":[{"name":"Medical Department Geneplus\u2010Beijing  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1700-9549","authenticated-orcid":false,"given":"Lin","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Peking Union Medical College Hospital Chinese Academy of Medical Sciences &amp; Peking Union Medical College  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pathology, Peking Union Medical College Hospital Chinese Academy of Medical Sciences &amp; Peking Union Medical College  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunmei","family":"Bai","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Peking Union Medical College Hospital Chinese Academy of Medical Sciences &amp; Peking Union Medical College  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,5,27]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtho.2023.01.095"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.21037\/tlcr-22-233"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(20)30515-4"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-021-02905-3"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/oncolo\/oyac099"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)32714-8"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(23)00446-1"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2019.02.001"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-19-0103"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-21-1466"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2019.303644"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1121557"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-22-2469"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.01638"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13046-022-02566-0"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41416-022-01979-0"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lungcan.2020.09.026"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1136\/jitc-2022-006035"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.21037\/tlcr-22-629"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.4143\/crt.2022.1647"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2023.1156999"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.631483"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1158\/2326-6066.CIR-19-0398"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2021.537735"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.3364"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-021-01541-0"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3520"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2015.121"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.5953"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0179726"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-25894-9"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2020.03.017"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-98414-w"},{"key":"e_1_2_9_35_1","first-page":"7:e152631","article-title":"Predictive value of TCR Vbeta\u2010Jbeta profile for adjuvant gefitinib in EGFR mutant NSCLC from ADJUVANT\u2010CTONG 1104 trial.","author":"Chen C","year":"2022","journal-title":"Insight"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1158\/2326-6066.CIR-18-0136"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41388-022-02277-y"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-20-1767"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2022.995651"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40425-015-0070-4"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.24939"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.3727\/096368916X690467"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.adi0258"}],"container-title":["Thoracic Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1759-7714.15326","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,3]],"date-time":"2024-07-03T04:18:04Z","timestamp":1719980284000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1759-7714.15326"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,27]]},"references-count":42,"journal-issue":{"issue":"19","published-print":{"date-parts":[[2024,7]]}},"alternative-id":["10.1111\/1759-7714.15326"],"URL":"https:\/\/doi.org\/10.1111\/1759-7714.15326","archive":["Portico"],"relation":{},"ISSN":["1759-7706","1759-7714"],"issn-type":[{"value":"1759-7706","type":"print"},{"value":"1759-7714","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,5,27]]},"assertion":[{"value":"2024-01-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-04-22","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-05-27","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}