{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T23:44:03Z","timestamp":1793317443670,"version":"4.5.0"},"reference-count":23,"publisher":"Wiley","issue":"21","license":[{"start":{"date-parts":[[2024,6,17]],"date-time":"2024-06-17T00:00:00Z","timestamp":1718582400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005006","name":"Asan Institute for Life Sciences, Asan Medical Center","doi-asserted-by":"publisher","award":["2023IP0073"],"award-info":[{"award-number":["2023IP0073"]}],"id":[{"id":"10.13039\/501100005006","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Thoracic Cancer"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Electromagnetic navigation bronchoscopy (ENB) and radial probe endobronchial ultrasound (RP\u2010EBUS) are essential bronchoscopic procedures for diagnosing peripheral lung lesions. Despite their individual advantages, the optimal circumstances for their combination remain uncertain.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This single\u2010center retrospective study enrolled 473 patients with 529 pulmonary nodules who underwent ENB and\/or RP\u2010EBUS biopsies between December 2021 and December 2022. Diagnostic yield was calculated using strict, intermediate, and liberal definitions. In the strict definition, only malignant and specific benign lesions were deemed diagnostic at the time of the index procedure. The intermediate and liberal definitions included additional results from the follow\u2010up period.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The diagnostic yield of the strict definition was not statistically different among the three groups (ENB\/Combination\/RP\u2010EBUS 63.8%\/64.2%\/62.6%, <jats:italic>p<\/jats:italic>\u2009=\u20090.944). However, the diagnostic yield was superior in the ENB\u2009+\u2009RP\u2010EBUS group for nodules with a bronchus type II or III and a solid part &lt;20\u2009mm (odds ratio 1.96, 95% confidence interval 1.09\u20133.53, <jats:italic>p<\/jats:italic>\u2009=\u20090.02). In terms of complications, bleeding was significantly higher in the ENB\u2009+\u2009RP\u2010EBUS group (ENB\/Combination\/RP\u2010EBUS 3.7% \/6.2\/0.6%, <jats:italic>p<\/jats:italic>\u2009=\u20090.002), but no major adverse event was observed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The combination of ENB and RP\u2010EBUS enhanced the diagnostic yield for nodules with bronchus type II or III and solid part &lt;20\u2009mm, despite a slightly elevated risk of bleeding. Careful patient selection based on nodule characteristics is important to benefit from this combined approach.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1759-7714.15376","type":"journal-article","created":{"date-parts":[[2024,6,18]],"date-time":"2024-06-18T04:30:13Z","timestamp":1718685013000},"page":"1638-1645","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Optimal approach for diagnosing peripheral lung nodules by combining electromagnetic navigation bronchoscopy and radial probe endobronchial ultrasound"],"prefix":"10.1111","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1381-7506","authenticated-orcid":false,"given":"Bora","family":"Lee","sequence":"first","affiliation":[{"name":"Division of Pulmonology and Critical Care Medicine, Department of Internal Medicine, Asan Medical Center University of Ulsan College of Medicine  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9486-9214","authenticated-orcid":false,"given":"Hee Sang","family":"Hwang","sequence":"additional","affiliation":[{"name":"Department of Pathology, Asan Medical Center University of Ulsan College of Medicine  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8239-4362","authenticated-orcid":false,"given":"Se Jin","family":"Jang","sequence":"additional","affiliation":[{"name":"Department of Pathology, Asan Medical Center University of Ulsan College of Medicine  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7720-4595","authenticated-orcid":false,"given":"Sang Young","family":"Oh","sequence":"additional","affiliation":[{"name":"Department of Radiology, Asan Medical Center University of Ulsan College of Medicine  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0691-5546","authenticated-orcid":false,"given":"Mi Young","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Radiology, Asan Medical Center University of Ulsan College of Medicine  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2881-4669","authenticated-orcid":false,"given":"Chang\u2010Min","family":"Choi","sequence":"additional","affiliation":[{"name":"Division of Pulmonology and Critical Care Medicine, Department of Internal Medicine, Asan Medical Center University of Ulsan College of Medicine  Seoul Korea"},{"name":"Department of Oncology, Asan Medical Center University of Ulsan College of Medicine  Seoul South 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