{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,21]],"date-time":"2026-06-21T03:16:11Z","timestamp":1782011771040,"version":"3.54.5"},"reference-count":20,"publisher":"Wiley","issue":"20","license":[{"start":{"date-parts":[[2024,6,5]],"date-time":"2024-06-05T00:00:00Z","timestamp":1717545600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Thoracic Cancer"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>This study aimed to investigate the effects of immune checkpoint inhibitors (ICIs) versus chemotherapy on the prognosis of real\u2010world diffuse pleural mesothelioma patients in China.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Clinical data of 90 patients with diffuse pleural mesothelioma from 2019 to 2022 were collected from Harbin Medical University Cancer Hospital. Patients were divided into two groups: the ICIs\u2010treated group (<jats:italic>n<\/jats:italic>\u2009=\u200946) and the chemotherapy\u2010only group (<jats:italic>n<\/jats:italic>\u2009=\u200944). The efficacy and safety of immunotherapy relative to chemotherapy at different treatment stages were explored.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The median progression\u2010free survival (PFS) was 10.0 and 7.0\u2009months, and the median overall survival (OS) was 24.7 and 15.8\u2009months in the ICIs\u2010treated group and the chemotherapy group, respectively. The ICIs\u2010treated group showed an 11% increase in objective response rate (ORR) (52.2% vs. 41.0%) and an 8.0% increase in disease control rate (DCR) (78.3% vs. 70.0%) compared to the chemotherapy group. The Kaplan\u2013Meier curves demonstrated significant PFS (HR: 0.61; 95% CI: 0.38\u20130.98; <jats:italic>p<\/jats:italic>\u2009=\u20090.038) and OS (HR: 0.47; 95% CI: 0.26\u20130.86; <jats:italic>p<\/jats:italic>\u2009=\u20090.011) benefits of receiving immunotherapy over chemotherapy alone. Subgroup analysis according to treatment timing showed the same trend.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In patients with nonsurgical diffuse pleural mesothelioma, immunotherapy achieved better survival benefits compared to chemotherapy in both first\u2010 and second\u2010\/third\u2010line treatments. The early addition of immunotherapy improved survival in patients with nonsurgical diffuse pleural mesothelioma.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1759-7714.15386","type":"journal-article","created":{"date-parts":[[2024,6,5]],"date-time":"2024-06-05T09:14:47Z","timestamp":1717578887000},"page":"1590-1597","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Comparative efficacy of immune checkpoint inhibitors versus chemotherapy alone in diffuse pleural mesothelioma"],"prefix":"10.1111","volume":"15","author":[{"given":"Xuemei","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology The Quzhou Affiliated Hospital of Wenzhou Medical University, Quzhou People's Hospital, RD. Minjiang, Dist. Kecheng  Quzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lele","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Medical Oncology Harbin Medical University Cancer Hospital  Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Medical Oncology Harbin Medical University Cancer Hospital  Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Thoracic Radiotherapy Harbin Medical University Cancer Hospital  Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wansu","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology The Quzhou Affiliated Hospital of Wenzhou Medical University, Quzhou People's Hospital, RD. Minjiang, Dist. Kecheng  Quzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-7502-1377","authenticated-orcid":false,"given":"Qingwei","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Medical Oncology Harbin Medical University Cancer Hospital  Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,6,5]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.thorsurg.2004.06.011"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)67025-0"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.4103\/0019-5278.146897"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lungcan.2005.03.002"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/590148"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/JTO.0000000000000506"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1105887108"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.5694\/mja11.10125"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/1758835920971421"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)01238-6"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)32714-8"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtho.2021.01.323"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lungcan.2021.06.017"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2021.39.15_suppl.9000"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-19-0103"},{"issue":"3","key":"e_1_2_9_17_1","article-title":"Clinical efficacy and safety of nivolumab in Japanese patients with malignant pleural mesothelioma: 3\u2010year results of the MERIT study","volume":"2","author":"Fujimoto N","year":"2020","journal-title":"JTO Clin Res Rep"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(21)00471-X"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtho.2018.08.277"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2020.09.009"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2018.5428"}],"container-title":["Thoracic Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1759-7714.15386","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,15]],"date-time":"2024-07-15T02:29:45Z","timestamp":1721010585000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1759-7714.15386"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,5]]},"references-count":20,"journal-issue":{"issue":"20","published-print":{"date-parts":[[2024,7]]}},"alternative-id":["10.1111\/1759-7714.15386"],"URL":"https:\/\/doi.org\/10.1111\/1759-7714.15386","archive":["Portico"],"relation":{},"ISSN":["1759-7706","1759-7714"],"issn-type":[{"value":"1759-7706","type":"print"},{"value":"1759-7714","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,6,5]]},"assertion":[{"value":"2024-03-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-05-08","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-06-05","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}