{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T15:33:58Z","timestamp":1790609638343,"version":"4.1.0"},"reference-count":34,"publisher":"Wiley","issue":"23","license":[{"start":{"date-parts":[[2024,7,7]],"date-time":"2024-07-07T00:00:00Z","timestamp":1720310400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Thoracic Cancer"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Clinically, most patients with lung cancer (LC) die from tumor spread and metastasis. Specific metastasis\u2010related molecules can provide reference for clinical prediction of efficacy, evaluation of prognosis, and search for the best treatment plan. Troponin T1 (TNNT1) is highly expressed in various cancer tissues, which affects malignant behavior of tumor cells and is related to patients' survival and prognosis. However, the role and molecular mechanism of TNNT1 in LC invasion and metastasis have not yet been investigated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Gene expression profiling interactive analysis (GEPIA) online analysis was used to analyze TNNT1 expression in LC tissues. Quantitative real\u2010time\u2010polymerase chain reaction (qRT\u2010PCR) or western blot were performed to measure TNNT1 or epithelial\u2010to\u2010mesenchymal transition (EMT)\u2010related and Wnt\/\u03b2\u2010catenin pathway\u2010related protein expression in LC cells. After TNNT1 knockdown, cell scratch healing and transwell assays were introduced to assess cell migration and invasion, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>TNNT1 expression in LC tissues and cells was increased. TNNT1 knockdown notably impaired LC cell migration, invasion and EMT. TNNT1 knockdown inhibited Wnt\/\u03b2\u2010catenin pathway of LC cells. Lithium chloride (LiCl) addition partially restored the inhibition of TNNT1 knockdown on migration, invasion, EMT and Wnt\/\u03b2\u2010catenin of LC cells.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>TNNT1 knockdown attenuated LC migration, invasion and EMT, possibly through Wnt\/\u03b2\u2010catenin signaling.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1759-7714.15400","type":"journal-article","created":{"date-parts":[[2024,7,8]],"date-time":"2024-07-08T06:15:52Z","timestamp":1720419352000},"page":"1749-1756","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["<scp>TNNT1<\/scp> accelerates migration, invasion and <scp>EMT<\/scp> progression in lung cancer cells"],"prefix":"10.1111","volume":"15","author":[{"given":"Xiaobin","family":"Ge","sequence":"first","affiliation":[{"name":"Department of Acupuncture\u2010Moxibustion and Tuina Qilu Hospital of Shandong University  Jinan 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