{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T21:39:49Z","timestamp":1771969189535,"version":"3.50.1"},"reference-count":48,"publisher":"Wiley","issue":"24","license":[{"start":{"date-parts":[[2024,7,16]],"date-time":"2024-07-16T00:00:00Z","timestamp":1721088000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004391","name":"China Medical University Hospital","doi-asserted-by":"publisher","award":["DMR\u2010113\u2010189"],"award-info":[{"award-number":["DMR\u2010113\u2010189"]}],"id":[{"id":"10.13039\/501100004391","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Thoracic Cancer"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>The use of stereotactic ablative radiotherapy (SABR) over conventional fractionated radiotherapy (CFRT) for early\u2010stage non\u2010small\u2010cell lung cancer (NSCLC) has been advocated, but is also debated in the literature.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this retrospective cohort study, we adopted a target trial emulation framework to identify eligible patients diagnosed between 2011 and 2021 using the Taiwan Cancer Registry. In the primary analysis, the overall survival (OS) was the primary endpoint, whereas incidences of lung cancer mortality and radiation pulmonary toxicity were the secondary endpoints. Extensive supplementary analyses were also conducted.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We included 351 patients in the primary analysis and found that the OS was not significantly different between the SABR (<jats:italic>n<\/jats:italic>\u2009=\u2009290) and CFRT (<jats:italic>n<\/jats:italic>\u2009=\u200961) groups. The propensity score weighting adjusted hazard ratio of death was 0.75 (95% confidence interval 0.53\u20131.07, <jats:italic>p<\/jats:italic>\u2009=\u20090.118). The secondary endpoints and supplementary analyses showed no significant differences.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The OS of patients with early\u2010stage NSCLC treated with SABR was not significantly different from that of patients treated with CFRT alone. The results of the relevant ongoing clinical trials are eagerly awaited.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1759-7714.15404","type":"journal-article","created":{"date-parts":[[2024,7,17]],"date-time":"2024-07-17T00:43:30Z","timestamp":1721177010000},"page":"1779-1791","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Stereotactic ablative radiotherapy versus conventional fractionated radiotherapy for clinical early\u2010stage non\u2010small\u2010cell lung cancer: a population\u2010based study"],"prefix":"10.1111","volume":"15","author":[{"given":"Hung\u2010Jen","family":"Chen","sequence":"first","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine China Medical University Hospital  Taichung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen\u2010Chien","family":"Cheng","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine China Medical University Hospital  Taichung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chih\u2010Yen","family":"Tu","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine China Medical University Hospital  Taichung Taiwan"},{"name":"School of Medicine, College of Medicine China Medical University  Taichung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Te\u2010Chun","family":"Hsia","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine China Medical University Hospital  Taichung Taiwan"},{"name":"Ph.D. Program for Health Science and Industry, College of Health Care China Medical University  Taichung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu\u2010Sen","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Chest Surgery China Medical University Hospital  Taichung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hsin\u2010Yuan","family":"Fang","sequence":"additional","affiliation":[{"name":"School of Medicine, College of Medicine China Medical University  Taichung Taiwan"},{"name":"Department of Chest Surgery China Medical University Hospital  Taichung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chia\u2010Chin","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology China Medical University Hospital  Taichung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2365-7641","authenticated-orcid":false,"given":"Chun\u2010Ru","family":"Chien","sequence":"additional","affiliation":[{"name":"School of Medicine, College of Medicine China Medical University  Taichung Taiwan"},{"name":"Department of Radiation Oncology China Medical University Hospital  Taichung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,7,16]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(21)00312-3"},{"key":"e_1_2_9_3_1","unstructured":"Cancer registry annual report; 2021. Taiwan.https:\/\/www.hpa.gov.tw\/File\/Attach\/17639\/File_23506.pdfAccessed December 18 2023."},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canrad.2021.11.005"},{"key":"e_1_2_9_5_1","unstructured":"National comprehensive cancer network guidelines for non\u2010small cell lung cancer version 1.2024.https:\/\/www.nccn.org\/professionals\/physician_gls\/pdf\/nscl.pdfAccessed January 7 2024."},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2012.10.006"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.3389\/pore.2024.1611709"},{"issue":"4","key":"e_1_2_9_8_1","article-title":"Stereotactic or conventional radiation for early\u2010stage non\u2010small cell lung cancer: a systematic review and meta\u2010analysis","volume":"15","author":"Mutsaers A","year":"2023","journal-title":"Cureus"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2016.08.015"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(18)30896-9"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1515\/raon-2017-0058"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000021715"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2022.21383"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.57264\/cer-2023-0189"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfma.2019.01.012"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.0000000000000152"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-0-387-88441-7"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-40618-3"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)61602-X"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/MLR.0000000000000824"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-031-35051-1_3"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.7819"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1177\/0962280218781171"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1080\/01621459.2016.1260466"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.9628"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/1475-6773.12182"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.8866"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.5984"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmpb.2003.10.004"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.7084"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.9519"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.7326\/M16-2607"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2018.21554"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12874-017-0367-8"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/pds.5339"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.8008"},{"key":"e_1_2_9_37_1","first-page":"51","volume-title":"Analysis of Observational Health Care Data Using SAS","author":"Austin PC","year":"2010"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2022.09.009"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph191912916"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2023.111228"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2021.3186"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfma.2020.12.028"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/1759-7714.14786"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1177\/1533033818806318"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.3892\/mco.2014.475"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1111\/1759-7714.15071"},{"key":"e_1_2_9_47_1","unstructured":"ESMO.Early\u2010stage and locally advanced (non\u2010metastatic) non\u2010small\u2010cell lung cancer: ESMO Clinical Practice Guidelines.https:\/\/www.esmo.org\/guidelines\/guidelines-by-topic\/esmo-clinical-practice-guidelines-lung-and-chest-tumours\/early-stage-and-locally-advanced-non-metastatic-non-small-cell-lung-cancerAccessed March 17 2024."},{"key":"e_1_2_9_48_1","unstructured":"Current number of NHS centers in the UK providing advanced radiotherapy with SABR for lung cancer.https:\/\/radiotherapy.org.uk\/wp\u2010content\/uploads\/2022\/08\/RTUK\u2010doc\u2010re\u2010NHS\u2010UK\u2010Centres\u2010providing\u2010SABR\u2010for\u2010lung\u2010cancer.pdfAccessed June 22 2024."},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.21873\/anticanres.12814"}],"container-title":["Thoracic Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1759-7714.15404","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,20]],"date-time":"2024-08-20T04:15:44Z","timestamp":1724127344000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1759-7714.15404"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,16]]},"references-count":48,"journal-issue":{"issue":"24","published-print":{"date-parts":[[2024,8]]}},"alternative-id":["10.1111\/1759-7714.15404"],"URL":"https:\/\/doi.org\/10.1111\/1759-7714.15404","archive":["Portico"],"relation":{},"ISSN":["1759-7706","1759-7714"],"issn-type":[{"value":"1759-7706","type":"print"},{"value":"1759-7714","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7,16]]},"assertion":[{"value":"2024-05-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-06-26","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-07-16","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}