{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T13:59:10Z","timestamp":1773237550249,"version":"3.50.1"},"reference-count":32,"publisher":"Wiley","issue":"28","license":[{"start":{"date-parts":[[2024,8,22]],"date-time":"2024-08-22T00:00:00Z","timestamp":1724284800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Thoracic Cancer"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Awareness of age\u2010related features of carcinogenesis and the importance of cellular immunity is crucial for developing effective antitumor therapies for specific patient groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this study, we examined different populations of cancer stem cells (CSCs) and circulating tumor cells (CTCs) in \"young\" (8\u201010\u2009weeks) and \"aged\" (80\u201082\u2009weeks) C57BL\/6 male mice. We used an orthotopic model of Lewis lung carcinoma (LLC) to evaluate the effectiveness of cell therapy targeting lung cancer through reprogrammed CD8\u2010positive T cells (rCD8+ T cells) in mice from two different ages.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The findings revealed that tumor progression with age is primarily caused by impaired recruitment of T cells to the lungs. Additionally, a lower number of CTCs and CSCs were observed in younger mice compared to the older mice. The antitumor effect of rCD8+ T cells in aged mice was found to be inferior to that in young mice, which can be attributed to the reduced impact of therapy on specific CSCs populations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>These results offer new insights into the treatment of lung cancer using rCD8+ T cells. Considering the age\u2010related characteristics influencing disease progression, this therapy has the potential to significantly enhance the effectiveness of treatment methods.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1759-7714.15426","type":"journal-article","created":{"date-parts":[[2024,8,22]],"date-time":"2024-08-22T17:09:32Z","timestamp":1724346572000},"page":"2000-2020","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Age\u2010related features of lung cancer treatment using reprogrammed <scp>CD8<\/scp> positive T cells in mice subjected to injection of Lewis lung carcinoma cells"],"prefix":"10.1111","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7445-4767","authenticated-orcid":false,"given":"Evgenii","family":"Skurikhin","sequence":"first","affiliation":[{"name":"Institute of General Pathology and Pathophysiology  Moscow 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