{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T13:39:27Z","timestamp":1790775567108,"version":"4.1.0"},"reference-count":23,"publisher":"Wiley","issue":"31","license":[{"start":{"date-parts":[[2024,9,19]],"date-time":"2024-09-19T00:00:00Z","timestamp":1726704000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["22K07291"],"award-info":[{"award-number":["22K07291"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["22K16583"],"award-info":[{"award-number":["22K16583"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Thoracic Cancer"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Superior outcomes have been obtained for neoadjuvant treatment with immune checkpoint inhibitors (ICI) plus chemotherapy over neoadjuvant chemotherapy alone, especially in patients with high programmed cell death ligand 1 (PD\u2010L1) expression. However, it is not always possible to obtain sufficient tumor specimens for biomarker testing before surgery. In this study, we explored clinical factors that can predict high PD\u2010L1 expression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively enrolled 340 lung cancer patients who received pulmonary resection between 2014 and 2023 and who had PD\u2010L1 expression data. Chi\u2010squared tests and logistic regression analyses were used to identify clinical factors associated with high PD\u2010L1 status.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Univariable and multivariable analyses revealed that smoking, high maximum standardized uptake value (SUVmax) of 18F\u2010fluorodeoxyglucose positron emission computed tomography (18F\u2010FDG PET\/CT), and high plasma fibrinogen are independent predictors of high PD\u2010L1 expression. A predictive score for high PD\u2010L1 expression (ranging from 0 to 3) was developed based on these parameters. Notably, only 5% of patients with a score of 0 exhibited high PD\u2010L1 expression, whereas this proportion increased to 53% for patients with a score of 3.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>These results showed that plasma fibrinogen, smoking history, and SUVmax are predictors of high PD\u2010L1 expression, providing a basis for identifying patients expected to benefit from neoadjuvant ICI treatment.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1759-7714.15453","type":"journal-article","created":{"date-parts":[[2024,11,8]],"date-time":"2024-11-08T02:44:28Z","timestamp":1731033868000},"page":"2229-2234","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Clinical factors associated with high <scp>PD<\/scp>\u2010<scp>L1<\/scp> expression in patients with early\u2010stage non\u2010small cell lung cancer"],"prefix":"10.1111","volume":"15","author":[{"given":"Shuta","family":"Ohara","sequence":"first","affiliation":[{"name":"Division of Thoracic Surgery, Department of Surgery Kindai University Faculty of Medicine  Osaka\u2010Sayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0842-8832","authenticated-orcid":false,"given":"Kenichi","family":"Suda","sequence":"additional","affiliation":[{"name":"Division of Thoracic Surgery, Department of Surgery Kindai University Faculty of Medicine  Osaka\u2010Sayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akira","family":"Hamada","sequence":"additional","affiliation":[{"name":"Division of Thoracic Surgery, Department of Surgery Kindai University Faculty of Medicine  Osaka\u2010Sayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masato","family":"Chiba","sequence":"additional","affiliation":[{"name":"Division of Thoracic Surgery, Department of Surgery Kindai University Faculty of Medicine  Osaka\u2010Sayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaoki","family":"Ito","sequence":"additional","affiliation":[{"name":"Division of Thoracic Surgery, Department of Surgery Kindai University Faculty of Medicine  Osaka\u2010Sayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaki","family":"Shimoji","sequence":"additional","affiliation":[{"name":"Division of Thoracic Surgery, Department of Surgery Kindai University Faculty of Medicine  Osaka\u2010Sayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiki","family":"Takemoto","sequence":"additional","affiliation":[{"name":"Division of Thoracic Surgery, Department of Surgery Kindai University Faculty of Medicine  Osaka\u2010Sayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junichi","family":"Soh","sequence":"additional","affiliation":[{"name":"Division of Thoracic Surgery, Department of Surgery Kindai University Faculty of Medicine  Osaka\u2010Sayama Japan"},{"name":"Department of Thoracic Surgery Osaka Metropolitan University Graduate School of Medicine  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhiro","family":"Tsutani","sequence":"additional","affiliation":[{"name":"Division of Thoracic Surgery, Department of Surgery Kindai University Faculty of Medicine  Osaka\u2010Sayama 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