{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T05:56:46Z","timestamp":1780466206180,"version":"3.54.1"},"reference-count":32,"publisher":"Wiley","issue":"32","license":[{"start":{"date-parts":[[2024,10,9]],"date-time":"2024-10-09T00:00:00Z","timestamp":1728432000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Thoracic Cancer"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Prophylactic cranial irradiation (PCI) was recommended for limited\u2010stage small\u2010cell lung cancer (SCLC) patients with complete or partial response to primary chemoradiotherapy. But it is still controversial regarding its role in SCLC patients who have had radical resection. This meta\u2010analysis aims to evaluate the efficacy of PCI in resected SCLC patients. We searched PubMed, EMBASE, Web of Science, CENTRAl, and ClinicalTrials for controlled trials and cohort studies regarding PCI in postoperative SCLC patients. The correlation between PCI and post\u2010operative outcomes in SCLC patients, including survival and brain metastasis rate (BMR), was examined using hazard ratios (HRs) and risk ratios with corresponding 95% confidence intervals. Quality of studies was assessed by the Newcastle\u2013Ottawa Scale (NOS), and publication bias was assessed by Begg's test. Meta\u2010analysis of eight studies with 2688 patients in total showed PCI was associated with improved overall survival (OS) for resected SCLC (HR: 0.65, 95% CI: 0.57\u20130.75, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01). In addition, subgroup analysis on three studies including 923 patients confirmed the protective role of postoperative PCI in N0 SCLC patients (HR: 0.79, 95% CI: 0.61\u20130.97, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). There was also a significant reduction in BMR in the PCI group pooled from six studies (HR: 0.58, 95% CI: 0.40\u20130.85, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01). The use of PCI delayed brain recurrence and improved OS in patients with resected, stage I\u2010III SCLC. Importantly, patients with N0 SCLC can also benefit from postoperative PCI. In future studies, PCI's role in patients with resected N0 SCLC at different T stage may need to be explored.<\/jats:p>","DOI":"10.1111\/1759-7714.15463","type":"journal-article","created":{"date-parts":[[2024,10,9]],"date-time":"2024-10-09T07:34:33Z","timestamp":1728459273000},"page":"2309-2318","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Prophylactic cranial irradiation in patients with resected small\u2010cell lung cancer: A systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1388-3255","authenticated-orcid":false,"given":"Haoning","family":"Peng","sequence":"first","affiliation":[{"name":"Department of Thoracic Surgery West China Hospital, Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianqi","family":"Hao","sequence":"additional","affiliation":[{"name":"Department of Thoracic 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