{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:30:15Z","timestamp":1747182615085,"version":"3.40.5"},"reference-count":14,"publisher":"Wiley","issue":"33","license":[{"start":{"date-parts":[[2024,10,11]],"date-time":"2024-10-11T00:00:00Z","timestamp":1728604800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Thoracic Cancer"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>We investigated the clinical outcomes of involved\u2010field high\u2010dose (\u226566\u2009Gy) chemoradiotherapy (CRT) combined with respiratory motion management for esophageal squamous cell carcinoma (ESCC).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients who underwent definitive CRT for histologically confirmed ESCC in our department between 2012 and 2018 were retrospectively analyzed. Respiratory motion management strategies included breath\u2010holding (63%) and mask immobilization (29%) based on individual measurements of respiratory tumor motion using radiographic fluoroscopy with endoscopically placed clip markers as landmarks. We evaluated patient characteristics, treatment efficacy, failure patterns, and toxicities.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We enrolled 35 patients with a prescribed dose of 66\u201370\u2009Gy in 33\u201335 fractions. The overall response rate within 6\u2009months post\u2010CRT was 94.3%; the median follow\u2010up period for survivors was 43\u2009months. The 2\u2010year overall survival (OS), progression\u2010free survival, and locoregional failure\u2010free survival rates were 51.4%, 42.9%, and 42.9%, respectively. A significant difference in OS was observed between patients with and without esophageal fistulas after CRT (<jats:italic>p<\/jats:italic>\u2009=\u20090.002, log\u2010rank test). Disease failure occurred in 16 patients (45.7%), including one (2.9%) with out\u2010of\u2010field regional nodal failure. Major grade 3 or higher toxicities included decreased white blood cell count (48.6%), neutrophil count (34.3%), and esophageal stenosis (31.4%). No grade 3 or higher cardiopulmonary toxicities were observed. Bronchial\/tracheal tumor compression and a higher radiotherapy dose (70\u2009Gy) were significantly correlated with esophageal fistulas.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Involved\u2010field high\u2010dose CRT with respiratory motion management may be a feasible treatment option for ESCC. However, a comprehensive assessment of esophageal fistula risk is required to identify suitable candidates.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1759-7714.15468","type":"journal-article","created":{"date-parts":[[2024,10,11]],"date-time":"2024-10-11T10:34:15Z","timestamp":1728642855000},"page":"2365-2374","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Involved\u2010field high\u2010dose chemoradiotherapy with respiratory motion management for esophageal squamous cell carcinoma"],"prefix":"10.1111","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-2694-1829","authenticated-orcid":false,"given":"Masaki","family":"Matsuda","sequence":"first","affiliation":[{"name":"Department of Radiology University of Yamanashi  Ch\u016b\u014d Yamanashi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takafumi","family":"Komiyama","sequence":"additional","affiliation":[{"name":"Department of Radiology University of Yamanashi  Ch\u016b\u014d Yamanashi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kan","family":"Marino","sequence":"additional","affiliation":[{"name":"Department of Radiology University of Yamanashi  Ch\u016b\u014d Yamanashi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinichi","family":"Aoki","sequence":"additional","affiliation":[{"name":"Department of Radiology University of Yamanashi  Ch\u016b\u014d Yamanashi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoko","family":"Akita","sequence":"additional","affiliation":[{"name":"Department of Radiology University of Yamanashi  Ch\u016b\u014d Yamanashi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoki","family":"Sano","sequence":"additional","affiliation":[{"name":"Department of Radiology University of Yamanashi  Ch\u016b\u014d Yamanashi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hidekazu","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Department of Radiology University of Yamanashi  Ch\u016b\u014d Yamanashi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8636-4045","authenticated-orcid":false,"given":"Masahide","family":"Saito","sequence":"additional","affiliation":[{"name":"Department of Radiology University of Yamanashi  Ch\u016b\u014d Yamanashi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hikaru","family":"Nemoto","sequence":"additional","affiliation":[{"name":"Department of Radiology University of Yamanashi  Ch\u016b\u014d Yamanashi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Onishi","sequence":"additional","affiliation":[{"name":"Department of Radiology University of Yamanashi  Ch\u016b\u014d Yamanashi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,10,11]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21660"},{"key":"e_1_2_10_3_1","unstructured":"National Cancer Registry (Ministry of Health Labour and Welfare) Tabulated by Cancer Information Service National Cancer Center Japan.Cancer statistics in Japan.https:\/\/ganjoho.jp\/reg_stat\/statistics\/data\/dl\/en.html. 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