{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:30:15Z","timestamp":1747182615720,"version":"3.40.5"},"reference-count":22,"publisher":"Wiley","issue":"34","license":[{"start":{"date-parts":[[2024,10,19]],"date-time":"2024-10-19T00:00:00Z","timestamp":1729296000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Thoracic Cancer"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Paraneoplastic neurological syndrome (PNS) is associated with small\u2010cell lung cancer (SCLC). However, the frequency and characteristics of PNS and the efficacy of anticancer treatment for these patients have not been investigated in the Japanese\/Asian population previously. Therefore, we aimed to better understand PNS by evaluating real\u2010world data from patients with PNS complicated by SCLC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients diagnosed with Stage II\u2013IV SCLC at a single center between August 2007 and April 2021 were retrospectively analyzed. The primary outcome was the incidence of PNS. The secondary outcomes were the change in performance status (PS) after treatment commencement and outcomes following anticancer treatment, including objective response rate (ORR), progression\u2010free survival (PFS), and overall survival (OS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 318 patients were evaluated; PNS was present in 2.8% (<jats:italic>n<\/jats:italic>\u2009=\u20099) of the overall population. All patients with PNS exhibited poor Eastern Cooperative Oncology Group PS (\u22652); moreover, 78% of patients had a PS score of 3\u20134. An improvement in PS was observed in 56% (<jats:italic>n<\/jats:italic>\u2009=\u20095) of patients. Patients with PNS exhibited treatment efficacies similar to patients without PNS (ORR: 89% vs. 83%, <jats:italic>p<\/jats:italic>\u2009=\u20091.0; PFS: 7.6 vs. 5.7\u2009months, <jats:italic>p<\/jats:italic>\u2009=\u20090.69; OS: not reached vs. 15.6\u2009months, <jats:italic>p<\/jats:italic>\u2009=\u20090.23).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>A total of 2.8% of patients had SCLC complicated by PNS, with poor PS observed. However, anticancer therapy led to an improvement in PS and comparable ORR, as well as PFS and OS similar to those observed in patients without PNS. Thus, anticancer therapy should be considered in patients with PNS.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1759-7714.15472","type":"journal-article","created":{"date-parts":[[2024,10,19]],"date-time":"2024-10-19T08:28:51Z","timestamp":1729326531000},"page":"2418-2427","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Paraneoplastic neurological syndrome and its impact on the treatment outcomes of small\u2010cell lung cancer: A single\u2010center retrospective analysis"],"prefix":"10.1111","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7829-7524","authenticated-orcid":false,"given":"Yuki","family":"Sato","sequence":"first","affiliation":[{"name":"Department of Respiratory Medicine Kobe City Medical Center General Hospital  Kobe Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoru","family":"Fujiwara","sequence":"additional","affiliation":[{"name":"Department of Neurology Kobe City Medical Center General Hospital  Kobe Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chigusa","family":"Shirakawa","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Kobe City Medical Center General Hospital  Kobe Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryosuke","family":"Hirabayashi","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Kobe City Medical Center General Hospital  Kobe Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuma","family":"Nagata","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Kobe City Medical Center General Hospital  Kobe Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atsushi","family":"Nakagawa","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Kobe City Medical Center General Hospital  Kobe 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