{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T03:27:24Z","timestamp":1768534044282,"version":"3.49.0"},"reference-count":23,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,12,17]],"date-time":"2024-12-17T00:00:00Z","timestamp":1734393600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"publisher","award":["22Y11911400"],"award-info":[{"award-number":["22Y11911400"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82272007"],"award-info":[{"award-number":["82272007"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Thoracic Cancer"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>This study aims to investigate the factors influencing false\u2010negative results in ultrasound\u2010guided percutaneous transthoracic needle lung biopsy results (US\u2010PTLB).<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>This ambispective cohort study included patients with subpleural pulmonary lesions who underwent US\u2010PTLB with benign pathological findings between April 2017 and June 2022 (retrospective cohort) and between July 2022 and October 2022 (prospective cohort). In the retrospective cohort, comparative and logistic regression analyses were performed to identify independent risk factors for false\u2010negative biopsy results. Stratified analyses based on these risk factors were performed in the prospective cohort.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The retrospective cohort included 1747 (true\u2010negative: false\u2010negative, 1321:426) patients with negative biopsy results, which were analyzed by comparative and logistic regression analyses, and the results demonstrated that advanced age (&gt;\u200956\u2009years) (OR\u2009=\u20091.08, 95% CI: 1.07\u20131.09), small\u2010sized lesions (&lt;\u20093\u2009cm) (OR\u2009=\u20091.80, 95% CI: 1.38\u20132.34), lesions with necrosis (OR\u2009=\u20093.00, 95% CI: 2.29\u20133.92), contrast\u2010enhanced ultrasound (CEUS) showing hyper\u2010enhancement (OR\u2009=\u20095.87, 95% CI: 4.09\u20138.42) or iso\u2010enhancement (OR\u2009=\u20092.81, 95% CI: 2.05\u20133.83), and the presence of hemoptysis (OR\u2009=\u200911.82, 95% CI: 5.16\u201327.08) or pneumothorax (OR\u2009=\u20097.90, 95% CI: 2.89\u201321.58) during the puncture were independent predictors of false\u2010negative US\u2010PTLB results. The results of stratified analyses in the prospective cohort were consistent with the retrospective cohort.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Risk factors associated with false\u2010negative results included advanced age (&gt;\u200956\u2009years), small\u2010sized lesion (&lt;\u20093\u2009cm), presence of necrosis in the lesion, CEUS showing hyper\u2010enhancement or iso\u2010enhancement of the lesion, and hemoptysis or pneumothorax during puncture.<\/jats:p><jats:p><jats:bold>Trial Registration:<\/jats:bold> Number: ChiCTR2000029749<\/jats:p><\/jats:sec>","DOI":"10.1111\/1759-7714.15506","type":"journal-article","created":{"date-parts":[[2024,12,17]],"date-time":"2024-12-17T11:53:52Z","timestamp":1734436432000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Identifying Risk Factors Associated With False\u2010Negative Results in <scp>US<\/scp>\u2010Guided Percutaneous Transthoracic Needle Lung Biopsy of Subpleural Pulmonary Lesions"],"prefix":"10.1111","volume":"16","author":[{"given":"Jiawei","family":"Yi","sequence":"first","affiliation":[{"name":"Department of Ultrasonography Shanghai Pulmonary Hospital of Tongji University School of Medicine  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mengjun","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Ultrasonography Shanghai Pulmonary Hospital of Tongji University School of Medicine  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junhui","family":"He","sequence":"additional","affiliation":[{"name":"Department of Ultrasonography Shanghai Pulmonary Hospital of Tongji University School of Medicine  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Runhe","family":"Xia","sequence":"additional","affiliation":[{"name":"Department of Ultrasonography Shanghai Pulmonary Hospital of Tongji University School of Medicine  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinyu","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Ultrasonography Shanghai Pulmonary Hospital of Tongji University School of Medicine  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6412-4227","authenticated-orcid":false,"given":"Yin","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Ultrasonography Shanghai Pulmonary Hospital of Tongji University School of Medicine  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,12,17]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21660"},{"issue":"1","key":"e_1_2_12_3_1","first-page":"81","article-title":"Subpleural lung tumors ultrasonography","volume":"12","author":"Rednic 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