{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T13:56:27Z","timestamp":1778507787409,"version":"3.51.4"},"reference-count":14,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,12,17]],"date-time":"2024-12-17T00:00:00Z","timestamp":1734393600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Thoracic Cancer"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>We herein describe a patient with non\u2010small\u2010cell lung cancer who achieved pCR with a single dose of pembrolizumab\u2010based chemoimmunotherapy followed by surgery. A 61\u2010year\u2010old man was referred to our hospital with wheezing and an abnormal chest shadow. Squamous cell carcinoma of the left lower lobe, cT2aN1M0 stage IIB, was diagnosed and pembrolizumab\u2010based chemoimmunotherapy was initiated at the patient's request. One month later, chest CT revealed new ground\u2010glass opacities of the lungs, which were judged to be a CTCAE grade 2 pneumonitis due to an immune\u2010related adverse event (irAE). Therefore, steroid therapy was initiated. Prednisolone was tapered and discontinued as symptoms improved. A sleeve resection of the left lower lobe was performed, and a pathological complete response (pCR) was confirmed in a resected specimen. There has been no recurrence for 1\u2009year and 7\u2009months without treatment. This is the first case report of pCR to a single dose of chemoimmunotherapy followed by surgery for lung cancer. The present results suggest the potential of a single dose of chemoimmunotherapy to achieve pCR and cause irAEs in some patients.<\/jats:p>","DOI":"10.1111\/1759-7714.15519","type":"journal-article","created":{"date-parts":[[2024,12,17]],"date-time":"2024-12-17T11:43:51Z","timestamp":1734435831000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Pathological Complete Response to a Single Dose of Pembrolizumab\u2010Based Chemoimmunotherapy for Squamous Cell Carcinoma of the Lung: A Case Report"],"prefix":"10.1111","volume":"16","author":[{"given":"Yugo","family":"Matsumura","sequence":"first","affiliation":[{"name":"Department of Respiratory Medicine National Hospital Organization Kochi Hospital  Kochi City Kochi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seiya","family":"Ichihara","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine National Hospital 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