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Most gastrointestinal metastases (GIM) from LC are found on the basis of primary LC. GIM of LC with GI symptoms as the initial symptom is extremely rare. Moreover, the overall survival time of lung cancer patients developing intestinal metastases is from 5\u2009weeks to 1\u2009year, and most patients will die within the first 6\u2009months. This report describes an uncommon case of lung adenocarcinoma that metastasized to the colon with initial symptoms involving the GI tract. After immunotherapy, the condition was stable for more than 2\u2009years, and he is currently in good condition.<\/jats:p>","DOI":"10.1111\/1759-7714.15531","type":"journal-article","created":{"date-parts":[[2025,1,20]],"date-time":"2025-01-20T03:05:47Z","timestamp":1737342347000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Colorectal Metastasis From Lung Adenocarcinoma With Initial Gastrointestinal Symptoms: A Case Report and Literature Review"],"prefix":"10.1111","volume":"16","author":[{"given":"Yu","family":"Xin","sequence":"first","affiliation":[{"name":"Department of Oncology The Second Hospital of Dalian Medical University  Dalian China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dan","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Oncology The Second Hospital of Dalian Medical University  Dalian China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dan","family":"Zang","sequence":"additional","affiliation":[{"name":"Department of Oncology The Second Hospital of Dalian Medical University  Dalian China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Oncology The Second Hospital of Dalian Medical University  Dalian China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-5297-6790","authenticated-orcid":false,"given":"Jun","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Oncology The Second Hospital of Dalian Medical University  Dalian China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,1,19]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12957-019-1611-y"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00432-008-0424-0"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v17.i38.4314"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2006.08.030"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2014.2830"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.08.1907"},{"issue":"6","key":"e_1_2_9_8_1","first-page":"9766","article-title":"Gastrointestinal Metastasis of Primary Lung Cancer: An Analysis of 366 Cases","volume":"15","author":"Hu Y.","year":"2018","journal-title":"Oncology Letters"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.suronc.2014.02.004"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/1759-7714.13468"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1556-0864(15)30037-X"}],"container-title":["Thoracic Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1759-7714.15531","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,30]],"date-time":"2025-01-30T22:47:55Z","timestamp":1738277275000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1759-7714.15531"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":10,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["10.1111\/1759-7714.15531"],"URL":"https:\/\/doi.org\/10.1111\/1759-7714.15531","archive":["Portico"],"relation":{},"ISSN":["1759-7706","1759-7714"],"issn-type":[{"type":"print","value":"1759-7706"},{"type":"electronic","value":"1759-7714"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"2024-10-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-01-05","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-01-19","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e15531"}}