{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T14:03:09Z","timestamp":1787580189360,"version":"build-2736575974"},"reference-count":45,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,2,12]],"date-time":"2025-02-12T00:00:00Z","timestamp":1739318400000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82141107\uff1a81972199"],"award-info":[{"award-number":["82141107\uff1a81972199"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Thoracic Cancer"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Malignant mesothelioma (MM) is a rare malignant tumor. To explore the clinicopathological characteristics and efficacy of Chinese population with MM in the real\u2010world.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Two hundred and forty\u2010eight patients diagnosed with MM between September 2007 and August 2024 from three large medical centers (Beijing Hospital, Peking University Cancer Hospital, and Chinese Academy of Medical Sciences Cancer Hospital) were retrospectively analyzed. Kaplan\u2013Meier and Cox regression were performed. Breast cancer gene 1\u2010associated protein 1 (\n                      <jats:italic>BAP1<\/jats:italic>\n                      ) status was evaluated.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Chinese population with MM had a lower diagnostic age, higher proportion of youth and female, more advanced stage and lower expression of characteristic markers. The median progression\u2010free survival (mPFS) and median overall survival (mOS) were 8.90 and 25.60\u2009months for the first\u2010line treatment, and 3.28 and 19.50\u2009months for the second\u2010line. The first\u2010line immunotherapy provided a relatively higher objective response rate (33.3% vs. 20.5%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.402) and a trend to prolong mPFS (12.10 vs. 9.20\u2009months,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.345) and mOS (NA vs. 23.90,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.185) compared with chemotherapy. Bevacizumab combined with chemotherapy relatively prolonged mPFS (10.47 vs. 7.93\u2009months,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.074) and mOS (31.30 vs. 23.20\u2009months,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.673) than chemotherapy alone. Carboplatin relatively improved mPFS than cisplatin (10.87 vs. 8.87\u2009months,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.185). Age and histologic type were predictors for PFS, and gender, histologic subtype, and CK5\/6 were prognosis factors for OS. Briefly, 17.78% patients existed\n                      <jats:italic>BAP1<\/jats:italic>\n                      deletions and correlated with OS benefit.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Chinese population with MM present unique clinicopathologic characteristics and could benefit from the first\u2010line immunotherapy and bevacizumab combined with chemotherapy. Gender, histologic subtype, and CK5\/6 are prognosis factors for OS.\n                      <jats:italic>BAP1<\/jats:italic>\n                      \u00a0deletions correlate with OS benefit.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/1759-7714.15533","type":"journal-article","created":{"date-parts":[[2025,2,12]],"date-time":"2025-02-12T23:45:11Z","timestamp":1739403911000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["A Multi\u2010Center Real\u2010World Study of Clinicopathologic Characteristics and Efficacy of the Malignant Mesothelioma in Chinese Population"],"prefix":"10.1111","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-6776-7797","authenticated-orcid":false,"given":"Chenrui","family":"Sun","sequence":"first","affiliation":[{"name":"Center of Biotherapy, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine Chinese Academy of Medical Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2768-1865","authenticated-orcid":false,"given":"Xue","family":"Yang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education\/Beijing), Department I of Thoracic Oncology Peking University Cancer Hospital &amp; Institute  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lan","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Pathology, Beijing Hospital, National Center of Gerontology; Institute of Geriatric Medicine Chinese Academy of Medical Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7337-2409","authenticated-orcid":false,"given":"Zhixin","family":"Bie","sequence":"additional","affiliation":[{"name":"Minimally Invasive Tumor Therapies Center, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine Chinese Academy of Medical Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Runting","family":"Kang","sequence":"additional","affiliation":[{"name":"Center of Biotherapy, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine Chinese Academy of Medical Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7257-751X","authenticated-orcid":false,"given":"Bin","family":"Ai","sequence":"additional","affiliation":[{"name":"Department of Oncology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine Chinese Academy of Medical Science  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junling","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Oncology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine Chinese Academy of Medical Science  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zitong","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Oncology Binzhou Medical University Hospital  Binzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haolan","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Oncology Binzhou Medical University Hospital  Binzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juanjuan","family":"Liu","sequence":"additional","affiliation":[{"name":"Center of Biotherapy, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine Chinese Academy of Medical Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0464-3754","authenticated-orcid":false,"given":"Jia","family":"Zhong","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Molecular Oncology, CAMS Key Laboratory of Translational Research on Lung Cancer, Department of Medical Oncology, National Cancer Center\/National Clinical Research Center for Cancer\/Cancer Hospital Chinese Academy of Medical Sciences Peking Union Medical College  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3353-1460","authenticated-orcid":false,"given":"Jiangyong","family":"Yu","sequence":"additional","affiliation":[{"name":"Center of Biotherapy, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine Chinese Academy of Medical Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,2,12]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/oemed\u20102023\u2010108983"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2023.1172496"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.21147\/j.issn.1000\u20109604.2017.04.09"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.4103\/0019\u20105278.146897"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2016.5487"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtho.2016.12.006"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.21.01567"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1821510116"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2022.01.074"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtocrr.2022.100280"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtocrr.2020.100075"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtho.2023.06.011"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2008.10.026"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btp698"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btp352"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.2514"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/bts271"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btr670"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21572"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/1759\u20107714.12967"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.912"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(00)04013\u20107"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.5858\/arpa.2017\u20100092\u2010OA"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078\u20100432.CCR\u201017\u20102169"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.21037\/tlcr.2019.11.29"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2017.2918"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers14061498"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtocrr.2020.100135"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2015.01.043"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2020.09.009"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213\u20102600(20)30515\u20104"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(15)01238\u20106"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2003.11.136"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1097\/JTO.0b013e31817c73d6"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.21037\/tlcr\u201020\u20101114"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctrv.2015.05.001"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pathol.2018.05.002"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.2147\/CLEP.S105396"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pathol.2022.01.010"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1111\/his.13763"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.asjsur.2018.10.009"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008\u20105472.CAN\u201008\u20103355"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078\u20100432.CCR\u201020\u20104037"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470\u20102045(22)00277\u20107"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtocrr.2021.100231"}],"container-title":["Thoracic Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1759-7714.15533","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,14]],"date-time":"2025-02-14T00:50:46Z","timestamp":1739494246000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1759-7714.15533"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2]]},"references-count":45,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,2]]}},"alternative-id":["10.1111\/1759-7714.15533"],"URL":"https:\/\/doi.org\/10.1111\/1759-7714.15533","archive":["Portico"],"relation":{},"ISSN":["1759-7706","1759-7714"],"issn-type":[{"value":"1759-7706","type":"print"},{"value":"1759-7714","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2]]},"assertion":[{"value":"2024-12-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-01-05","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-02-12","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e15533"}}