{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:42:32Z","timestamp":1787013752193,"version":"build-2736575974"},"reference-count":41,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,2,25]],"date-time":"2025-02-25T00:00:00Z","timestamp":1740441600000},"content-version":"vor","delay-in-days":24,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100018904","name":"Beijing Xisike Clinical Oncology Research Foundation","doi-asserted-by":"publisher","award":["Y\u2010Young2024\u20100371"],"award-info":[{"award-number":["Y\u2010Young2024\u20100371"]}],"id":[{"id":"10.13039\/100018904","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013290","name":"National Key Research and Development Program of China Stem Cell and Translational Research","doi-asserted-by":"publisher","award":["2021YFF1201001"],"award-info":[{"award-number":["2021YFF1201001"]}],"id":[{"id":"10.13039\/501100013290","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Thoracic Cancer"],"published-print":{"date-parts":[[2025,2]]},"abstract":"ABSTRACT<\/jats:title>\n \n Fibroblast Growth Factor (FGF) ligands and their receptor have been identified as the potent target in non\u2013small cell lung cancer (NSCLC). However, the clinicopathological and microenvironmental characteristics of\n FGF\/FGFR<\/jats:italic>\n in NSCLC remain poorly elucidated. Here, we summarize 4656 NSCLCs and analyze clinicopathological features in 478\n FGF\/FGFR<\/jats:italic>\n altered cases. AI analysis and multiplex immunofluorescence staining are used to reveal microenvironment features. First, around 10.27% NSCLC carry\n FGF\/FGFR<\/jats:italic>\n variant. Squamous cell carcinoma (41.95%) is much more than adenocarcinoma (8.32%). In 118 pathogenic variant (PV) cases, the most frequent variant is\n FGF\/FGFR<\/jats:italic>\n copy number increase (83.05%), the second is\n FGFR<\/jats:italic>\n gene fusion (11.86%). Surprisingly,\n CCND1<\/jats:italic>\n always co\u2010amplifies with\n FGF19<\/jats:italic>\n (100.00%). Furthermore,\n FGF<\/jats:italic>\n PV is an independent risk factor for poor outcomes (overall survival: HR\u2009=\u20093.781, disease\u2010free survival: HR\u2009=\u20093.340). And one\u2010third of\n FGFR3\u2010TACC3<\/jats:italic>\n fusion cases show clear cytoplasm in histology. Either\n CCND1\/FGF19<\/jats:italic>\n co\u2010amplification or\n KRAS<\/jats:italic>\n co\u2010mutation is closely related to cigarette exposure, and\n KRAS<\/jats:italic>\n co\u2010mutation acts as an independent factor of poor prognosis. Finally, the\n FGF\/FGFR1\/NOTCH1<\/jats:italic>\n within\n RB1<\/jats:italic>\n variant group has a remarkably high ratio of inner\u2010tumor CD8+ T cell infiltration, non\u2010exhausted T cells, exhausted T\n CD8+PD\u20101+LAG3\u2212<\/jats:sup>\n cells, and T\n RM<\/jats:sub>\n CD8+CD69+CD103+<\/jats:sup>\n cells. Overall, this study provides a comprehensive analysis of\n FGF\/FGFR<\/jats:italic>\n alteration in NSCLC. The\n FGF\/FGFR<\/jats:italic>\n alteration mainly arises\u00a0in squamous cell carcinoma. Both\n FGF<\/jats:italic>\n PV and\n KRAS<\/jats:italic>\n are the independent factors for poor prognosis. To our knowledge, this is the first report to describe an inflamed microenvironment recruited by\n NOTCH1<\/jats:italic>\n \/\n RB1<\/jats:italic>\n co\u2010mutation, indicating potential benefit from immunotherapy.\n <\/jats:p>","DOI":"10.1111\/1759-7714.70016","type":"journal-article","created":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T12:27:45Z","timestamp":1741696065000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["A Comprehensive Analysis of\n FGF<\/i>\n \/\n FGFR<\/i>\n Signaling Alteration in\n NSCLC<\/scp>\n : Implications in Prognosis and Microenvironment"],"prefix":"10.1111","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0899-1270","authenticated-orcid":false,"given":"Ziling","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Pathology Fudan University Shanghai Cancer Center Shanghai China"},{"name":"Department of Oncology Shanghai Medical College of Fudan University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leyao","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pathology Fudan University Shanghai Cancer Center Shanghai China"},{"name":"Department of Oncology Shanghai Medical College of Fudan University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu","family":"Cai","sequence":"additional","affiliation":[{"name":"Department of Pathology Fudan University Shanghai Cancer Center Shanghai China"},{"name":"Department of Oncology Shanghai Medical College of Fudan University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shen","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Computer Science Fudan University Shanghai China"},{"name":"Butiange Co. Ltd Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Jia","sequence":"additional","affiliation":[{"name":"Alpha X Biotech (Beijing) Co. Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pathology Fudan University Shanghai Cancer Center Shanghai China"},{"name":"Department of Oncology Shanghai Medical College of Fudan University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,2,25]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/cac2.12025"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21590"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21820"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/CM9.0000000000001474"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591\u2010021\u201001450\u20102"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/CM9.0000000000002108"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2020.103194"},{"key":"e_1_2_11_9_1","first-page":"167","article-title":"Molecular Diagnostics and Targeted Therapies in Non\u2010Small Cell Lung Cancer (NSCLC): An Update","volume":"27","author":"Jonna S.","year":"2019","journal-title":"Discovery 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