{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T02:21:28Z","timestamp":1790216488214,"version":"4.1.0"},"reference-count":36,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,3,21]],"date-time":"2025-03-21T00:00:00Z","timestamp":1742515200000},"content-version":"vor","delay-in-days":20,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Thoracic Cancer"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>This study explored the safety and efficacy of combining radiotherapy with sintilimab in non\u2010small cell lung cancer (NSCLC)\u00a0patients who have progressed after first or second\u2010line therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this multicenter, single\u2010arm trial, patients with NSCLC who had progressed after first or second\u2010line therapy were enrolled. Participants received hypofractionated stereotactic body radiotherapy (SBRT) (requiring a single\u2010site biological dose of more than 30\u2009Gy or planned to reach 30\u2009Gy) followed by sintilimab every 3\u2009weeks until disease progression or unacceptable toxicity occurred.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>From March 1, 2019, to July 27, 2023, 14 patients were enrolled across two centers. The cohort included 64.3% males and 35.7% females, with a median age of 67\u2009years (range 57\u201373\u2009years). All participants completed radiation therapy and received at least one cycle of sintilimab. The overall response rate (ORR) was 21.4% (3\/14) and the disease control rate (DCR) was 71.4% (10\/14). The absent radiation response (ARR) was 14.3% (2\/14). The median PFS was 4.17\u2009months (95% CI: 1.15\u20138.69\u2009months), with a 6\u2010month PFS rate of 42.9%. The median OS was 16.17\u2009months (95% CI: 11.69\u201320.64\u2009months). Overall, 10 patients (71.4%) experienced at least one treatment\u2010emergent adverse event (TEAE). Grade 3 adverse events included one case each of immune\u2010related myocarditis, thrombocytopenia, and checkpoint inhibitor pneumonitis (CIP). Four patients (28.6%) had immune\u2010related adverse events (irAEs) including skin rash and pruritus (2\/14, grade 1), immune\u2010related myocarditis (1\/14, grade 3), and CIP (1\/14, grade 3).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Radiotherapy combined with sintilimab for NSCLC patients who progressed after first\u2010or second\u2010line therapy showed promising efficacy outcomes.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1759-7714.70043","type":"journal-article","created":{"date-parts":[[2025,3,23]],"date-time":"2025-03-23T11:10:00Z","timestamp":1742728200000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Safety and Efficacy of Radiotherapy Combined With Sintilimab in Advanced <scp>NSCLC<\/scp> Patients Who Progressed on First or Second Line Therapy: A Prospective, Multiple Center, and Single\u2010Arm 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