{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:25:52Z","timestamp":1753878352114,"version":"3.41.2"},"reference-count":17,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,4,2]],"date-time":"2025-04-02T00:00:00Z","timestamp":1743552000000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Thoracic Cancer"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Patients with lung cancer often develop distant metastases; however, metastasis to the external auditory canal is rare. We report the case of a 77\u2010year\u2010old man who presented with left\u2010sided hearing loss, otalgia, and a red mass in the left external auditory canal. Computed tomography revealed masses in the left external auditory canal, lung, and pancreas. Histopathological analysis confirmed small cell lung cancer, with thyroid transcription factor 1 positivity in multiple lesions, suggesting a primary tumor in lung. Treatment with carboplatin and etoposide led to a reduction in metastatic lesions, including those in the external auditory canal, and improved hearing impairment. This case highlights a rare instance in which chemotherapy improved ear symptoms in a patient with small cell lung cancer metastasis to the external auditory. Written informed consent was obtained from the patient for the publication of this case report and accompanying images.<\/jats:p>","DOI":"10.1111\/1759-7714.70059","type":"journal-article","created":{"date-parts":[[2025,4,3]],"date-time":"2025-04-03T10:10:51Z","timestamp":1743675051000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Metastasis of Small Cell Lung Cancer to the External Auditory Canal: A Case Report"],"prefix":"10.1111","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5931-1813","authenticated-orcid":false,"given":"Toshiyuki","family":"Ito","sequence":"first","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine Mie University Faculty and Graduate School of Medicine  Tsu Mie Japan"},{"name":"Department of Respiratory Medicine Mie Prefectural General Medical Center  Yokkaichi Mie Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masamichi","family":"Yoshida","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Mie Prefectural General Medical Center  Yokkaichi Mie Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroto","family":"Miki","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Mie Prefectural General Medical Center  Yokkaichi Mie Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroki","family":"Goto","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Mie Prefectural General Medical Center  Yokkaichi Mie Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuuji","family":"Kodama","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Mie Prefectural General Medical Center  Yokkaichi Mie Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atsushi","family":"Fujiwara","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Mie Prefectural General Medical Center  Yokkaichi Mie Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hajime","family":"Fujimoto","sequence":"additional","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine Mie University Faculty and Graduate School of Medicine  Tsu Mie Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tetsu","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine Mie University Faculty and Graduate School of Medicine  Tsu Mie Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,4,2]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21660"},{"key":"e_1_2_11_3_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1177\/2050313X241258155","article-title":"External Auditory Canal Metastasis Revealing Bronchogenic Carcinoma: A Case Report and Literature Review","volume":"12","author":"Ayadi S.","year":"2024","journal-title":"SAGE Open Medical Case Reports"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348941312200606"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/014556131209101107"},{"key":"e_1_2_11_6_1","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1177\/000348946807700101","article-title":"Pathology of Secondary Malignant Tumors of the Temporal Bone","volume":"77","author":"Schuknecht H. 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