{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T16:28:13Z","timestamp":1790872093717,"version":"4.1.0"},"reference-count":25,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,5,2]],"date-time":"2025-05-02T00:00:00Z","timestamp":1746144000000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Thoracic Cancer"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Unresolved issues complicate treating limited\u2010stage small\u2010cell lung cancer (LS\u2010SCLC). We conducted a real\u2010world study analyzing LS\u2010SCLC treatment patterns to address clinical needs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We retrospectively enrolled patients with LS\u2010SCLC treated at Peking Union Medical College Hospital between May 2008 and December 2023. Information was collected on clinicopathological features, cancer\u2010related treatments, laboratory test results, and clinical and prognostic data. Kaplan\u2013Meier survival analysis was performed to evaluate progression\u2010free (PFS) and overall survival (OS). Cox regression models were used to assess the factors influencing survival.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among the 203 patients with LS\u2010SCLC, the median OS (mOS) was 28.8\u2009months. Log\u2010rank testing revealed significant mOS differences among radiotherapy timing groups (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.031): concurrent chemoradiotherapy (cCRT) 30.1\u2009months, sequential therapy 27.5\u2009months, and no radiotherapy 21.7\u2009months. Early cCRT showed a non\u2010significant mOS trend advantage over late cCRT (38.3 vs. 29.5\u2009months,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.058). Prophylactic cranial irradiation (PCI) demonstrated comparable mOS (36.9 vs. 29.6\u2009months,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.27). Peripheral blood biomarkers (PBBs) lacked prognostic significance. Multivariate analysis identified Eastern Cooperative Oncology Group (ECOG) performance status (PS)\u2009&gt;\u20091 (HR\u2009=\u20093.652, 95% CI 1.579\u20138.448;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.002) and N2\/N3 metastasis (N2: HR\u2009=\u20092.872, 95% CI 1.312\u20136.286,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.008; N3: HR\u2009=\u20092.645, 95% CI 1.195\u20135.856,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.016) as survival predictors. Sequential radiotherapy increased mortality risk versus early cCRT (HR\u2009=\u20091.701, 95% CI 1.125\u20132.573;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.012).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Performance status and lymph node metastasis are prognostic factors for patients with LS\u2010SCLC. cCRT improves the prognosis of LS\u2010SCLC, with early cCRT providing a significant survival benefit and late cCRT being an acceptable option.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/1759-7714.70070","type":"journal-article","created":{"date-parts":[[2025,5,2]],"date-time":"2025-05-02T08:22:38Z","timestamp":1746174158000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Real\u2010World Analysis of Treatment Patterns in Limited\u2010Stage Small Cell Lung Cancer: Implications for Clinical Practice"],"prefix":"10.1111","volume":"16","author":[{"given":"Siyuan","family":"Yu","sequence":"first","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyi","family":"Feng","sequence":"additional","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengjie","family":"Li","sequence":"additional","affiliation":[{"name":"Biomedical Engineering Facility of National Infrastructures for Translational Medicine Institute of Clinical Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyan","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoxing","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4040-6115","authenticated-orcid":false,"given":"Minjiang","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Zhong","sequence":"additional","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2832-2664","authenticated-orcid":false,"given":"Yan","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengzhao","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,5,2]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.21037\/tlcr\u201024\u201024"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21731"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2024.14555"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.2217\/fon.13.213"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clon.2022.08.024"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2024.110221"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/CCO.0000000000000910"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2023.1118371"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.2147\/JIR.S450804"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2023.1211752"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.21037\/tlcr\u201021\u2010710"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.21037\/apm.2020.04.31"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1272\/jnms.JNMS.2022_89\u2010507"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000002985"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.21037\/tlcr\u201020\u2010997"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdw263"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2006.07.029"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199908123410703"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.24105"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2020.1929"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.21.00639"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470\u20102045(17)30230\u20109"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471\u20102407\u20101\u20105"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cllc.2018.11.013"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.2217\/fon\u20102022\u20100523"}],"container-title":["Thoracic 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