{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:21:32Z","timestamp":1753878092647,"version":"3.41.2"},"reference-count":11,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,6,14]],"date-time":"2025-06-14T00:00:00Z","timestamp":1749859200000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Thoracic Cancer"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Pulmonary basaloid squamous cell carcinoma (BSCC) is a rare, high\u2010grade subtype of lung squamous cell carcinoma. It predominantly affects elderly male smokers and is usually diagnosed at an advanced stage. Here, we report an early\u2010stage BSCC in a 67\u2010year\u2010old non\u2010smoking female identified during routine health screening. Chest CT revealed a 30\u2010mm mass in the right lower lobe. PET\u2010CT showed mild FDG uptake without lymph node or distant metastasis. Bronchoscopy confirmed malignancy, and thoracoscopic lobectomy with mediastinal lymph node dissection was performed. Gross pathology demonstrated a polypoid tumor protruding into the bronchial lumen. Histologically, the tumor exhibited solid basaloid nests with peripheral palisading and a high nuclear\u2010to\u2010cytoplasmic ratio. Immunohistochemistry showed strong p63 and CK5\/6 positivity, with weak focal p40 expression in less than 20% of tumor cells. Ki\u201067 labeling index was approximately 50%. Neuroendocrine and breast cancer markers were negative. Mosaic p53 positivity was observed, and no actionable mutations were identified via next\u2010generation sequencing. The final diagnosis was primary pulmonary BSCC (pT1cN0M0, Stage IA3). The patient remains recurrence\u2010free 18\u2009months postoperatively without adjuvant therapy. A literature review of 11 representative reports revealed BSCC typically presents in older male smokers at later stages and carries a poor prognosis. This case highlights the potential for BSCC to occur in non\u2010smokers and at early stages, emphasizing the importance of a multidisciplinary diagnostic approach integrating histology, immunohistochemistry, and molecular data.<\/jats:p>","DOI":"10.1111\/1759-7714.70106","type":"journal-article","created":{"date-parts":[[2025,6,14]],"date-time":"2025-06-14T09:22:29Z","timestamp":1749892949000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Case of Pulmonary Basaloid Squamous Cell Carcinoma in a Non\u2010Smoking Female: Case Report and Literature Review"],"prefix":"10.1111","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-8128-4839","authenticated-orcid":false,"given":"Tsukasa","family":"Satoh","sequence":"first","affiliation":[{"name":"Department of Respiratory Medicine Yamanashi Kosei Hospital  Yamanashi City Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Watanabe","family":"Hiromu","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Yamanashi Kosei Hospital  Yamanashi City Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nakamura","family":"Kimie","sequence":"additional","affiliation":[{"name":"Department of Pathology Yamanashi Kosei Hospital  Yamanashi City Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mitsui","family":"Izumi","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Yamanashi Kosei Hospital  Yamanashi City Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nishikawa","family":"Keiichi","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Yamanashi Kosei Hospital  Yamanashi City Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chiba","family":"Shigehiro","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Yamanashi Kosei Hospital  Yamanashi City Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenzo","family":"Soejima","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Graduate School of Medicine University of Yamanashi  Yamanashi City Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,6,14]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0046-8177(92)90260-A"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00058507"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19940601)73:11<2734::AID-CNCR2820731114>3.0.CO;2-4"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.7717\/peerj.6724"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.2482\/haigan.59.137"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.2995\/jacsurg.27.748"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.2995\/jacsurg.36.791"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/JTO.0000000000000545"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2020.607130"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.2995\/jacsurg.29.129"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/1749-8090-6-10"}],"container-title":["Thoracic Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1759-7714.70106","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,20]],"date-time":"2025-06-20T03:16:38Z","timestamp":1750389398000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1759-7714.70106"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6]]},"references-count":11,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2025,6]]}},"alternative-id":["10.1111\/1759-7714.70106"],"URL":"https:\/\/doi.org\/10.1111\/1759-7714.70106","archive":["Portico"],"relation":{},"ISSN":["1759-7706","1759-7714"],"issn-type":[{"type":"print","value":"1759-7706"},{"type":"electronic","value":"1759-7714"}],"subject":[],"published":{"date-parts":[[2025,6]]},"assertion":[{"value":"2025-02-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-06-02","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-06-14","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70106"}}