{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T15:01:18Z","timestamp":1778770878301,"version":"3.51.4"},"reference-count":20,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,6,21]],"date-time":"2025-06-21T00:00:00Z","timestamp":1750464000000},"content-version":"vor","delay-in-days":20,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Thoracic Cancer"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Crizotinib, an anaplastic lymphoma kinase (ALK)\/ROS1\/c\u2010MET inhibitor, improves outcomes in ALK\u2010positive non\u2010small cell lung cancer (NSCLC) but can cause crizotinib\u2010associated renal cysts (CARCs), a rare yet clinically relevant adverse effect. We report a case of a 68\u2010year\u2010old Korean male who developed complex renal cysts after 4\u2009years of crizotinib therapy. Radiologic findings initially raised suspicion for either an abscess or a neoplastic lesion, leading to surgical resection. However, recurrent renal cysts developed during continued crizotinib therapy, and CARCs were subsequently suspected. A dose reduction was implemented, which led to cyst regression without compromising tumor control. This case highlights the need to recognize and manage late\u2010onset toxicities during long\u2010term treatment, emphasizing the clinical value of multidisciplinary evaluation and tailored dose adjustments.<\/jats:p>","DOI":"10.1111\/1759-7714.70111","type":"journal-article","created":{"date-parts":[[2025,6,21]],"date-time":"2025-06-21T03:14:25Z","timestamp":1750475665000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Late\u2010Onset Crizotinib\u2010Associated Renal Cysts With Subsequent Regression Following Dose Reduction: A Case Report"],"prefix":"10.1111","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-2152-2508","authenticated-orcid":false,"given":"Joon\u2010Young","family":"Yoon","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Division of Pulmonology Chonnam National University Medical School  Hwasun Jeonnam South Korea"},{"name":"Lung Cancer Center Chonnam National University Hwasun Hospital  Hwasun Jeonnam South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2821-2788","authenticated-orcid":false,"given":"Won Gi","family":"Jeong","sequence":"additional","affiliation":[{"name":"Lung Cancer Center Chonnam National University Hwasun Hospital  Hwasun Jeonnam South Korea"},{"name":"Department of Radiology Chonnam National University Medical School  Hwasun Jeonnam South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoo\u2010Duk","family":"Choi","sequence":"additional","affiliation":[{"name":"Lung Cancer Center Chonnam National University Hwasun Hospital  Hwasun Jeonnam South Korea"},{"name":"Department of Pathology Chonnam National University Medical School  Gwangju South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seung Ji","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Infectious Diseases Chonnam National University Medical School  Hwasun Jeonnam South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hwa Kyung","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Pulmonology Chonnam National University Medical School  Hwasun Jeonnam South Korea"},{"name":"Lung Cancer Center Chonnam National University Hwasun Hospital  Hwasun Jeonnam South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyung\u2010Joo","family":"Oh","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Pulmonology Chonnam National University Medical School  Hwasun Jeonnam South Korea"},{"name":"Lung Cancer Center Chonnam National University Hwasun Hospital  Hwasun Jeonnam South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheol\u2010Kyu","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Pulmonology Chonnam National University Medical School  Hwasun Jeonnam South Korea"},{"name":"Lung Cancer Center Chonnam National University Hwasun Hospital  Hwasun Jeonnam South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4837-1321","authenticated-orcid":false,"given":"In\u2010Jae","family":"Oh","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Pulmonology Chonnam National University Medical School  Hwasun Jeonnam South Korea"},{"name":"Lung Cancer Center Chonnam National University Hwasun Hospital  Hwasun Jeonnam South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7019-7687","authenticated-orcid":false,"given":"Young\u2010Chul","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Pulmonology Chonnam National University Medical School  Hwasun Jeonnam South Korea"},{"name":"Lung Cancer Center Chonnam National University Hwasun Hospital  Hwasun Jeonnam South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,6,21]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1158\/1535-7163.MCT-07-0365"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature05945"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2013.54.5921"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1214886"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.437"},{"issue":"9","key":"e_1_2_6_7_1","article-title":"Adverse Side Effects of Crizotinib in the Treatment of Anaplastic Lymphoma Kinase\u2010Mutated Non\u2010Small Cell Lung Cancer: A Systematic Review","volume":"15","author":"George S.","year":"2023","journal-title":"Cureus"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.5301\/jo-n.5000012"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19102902"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40360-025-00859-6"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinimag.2020.03.011"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/ccr3.4278"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40644-017-0109-5"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lungcan.2017.01.010"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/00041552-200201000-00004"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(94)92344-2"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/ckj\/sfac062"},{"key":"e_1_2_6_18_1","first-page":"89","article-title":"Alectinib Induced Regression of Renal and Hepatic Cysts Caused by Crizotinib","volume":"13","author":"Di Marino P.","year":"2020","journal-title":"Int Med Case Rep J"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13000-024-01480-7"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00261\u2010025\u201004894\u2010z"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctarc.2021.100373"}],"container-title":["Thoracic Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1759-7714.70111","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,22]],"date-time":"2025-07-22T08:36:40Z","timestamp":1753173400000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1759-7714.70111"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6]]},"references-count":20,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2025,6]]}},"alternative-id":["10.1111\/1759-7714.70111"],"URL":"https:\/\/doi.org\/10.1111\/1759-7714.70111","archive":["Portico"],"relation":{},"ISSN":["1759-7706","1759-7714"],"issn-type":[{"value":"1759-7706","type":"print"},{"value":"1759-7714","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6]]},"assertion":[{"value":"2025-03-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-06-05","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-06-21","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70111"}}