{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T22:18:08Z","timestamp":1790115488656,"version":"4.0.1"},"reference-count":23,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,6,25]],"date-time":"2025-06-25T00:00:00Z","timestamp":1750809600000},"content-version":"vor","delay-in-days":24,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Thoracic Cancer"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Repeated anatomical pulmonary resections in second primary nonsmall\u2010cell lung cancer (NSCLC) pose significant challenges due to prior surgery. This study evaluates the feasibility and short\u2010term outcomes of repeated anatomical pulmonary resections for second primary NSCLC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>We retrospectively reviewed all consecutive cases of repeated anatomical pulmonary resections for second primary NSCLC performed in our institution from January 2014 to December 2023.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 55 patients (median age 68\u2009years; interquartile range [<jats:styled-content style=\"fixed-case\">IQR]<\/jats:styled-content>: 61.5\u201372) underwent repeated anatomical pulmonary resections for second primary <jats:styled-content style=\"fixed-case\">NSCLC<\/jats:styled-content>. Adenocarcinoma predominated in both primary (78.2%) and secondary (76.4%) cases. Video\u2010assisted thoracoscopy (<jats:styled-content style=\"fixed-case\">VATS<\/jats:styled-content>) approach was used in 94.5% and 96.4% for first and repeated resection, respectively (<jats:italic>p<\/jats:italic>\u2009=\u20090.647). The extent of pulmonary resection differed between first and repeated resection, with a predominance of lobectomy during first resection (56.4%) and segmentectomy during repeated resection (85.5%, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). We did not observe any significant difference in postoperative overall morbidity after first and repeated resection (23.6% vs. 40%, <jats:italic>p<\/jats:italic>\u2009=\u20090.065). However, there was an increased incidence of atrial fibrillation (16.4% vs. 0%) and prolonged air leak (&gt;\u20095\u2009days) after repeated resection (25.5% vs. 5.5%, <jats:italic>p<\/jats:italic>\u2009=\u20090.008). The median length of hospital stay was similar after first and repeated resection (5 vs. 5\u2009days, <jats:italic>p<\/jats:italic>\u2009=\u20090.089). The three\u2010year overall survival (OS) was 73% after first resection and 87% after repeated resection. Overall disease recurrence rate was not statistically different between first and repeated resection (1.8% vs. 3.6%, <jats:italic>p<\/jats:italic>\u2009=\u20090.558).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our series demonstrated that second primary NSCLC can be safely managed by VATS segmentectomy, yielding favorable short\u2010term survival and low recurrence rates.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1759-7714.70116","type":"journal-article","created":{"date-parts":[[2025,6,25]],"date-time":"2025-06-25T23:45:15Z","timestamp":1750895115000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Repeated Anatomical Pulmonary Resection for Second Primary Nonsmall\u2010Cell Lung Cancer: Safety and Short\u2010Term Outcomes"],"prefix":"10.1111","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-4902-913X","authenticated-orcid":false,"given":"C\u00e9line","family":"Forster","sequence":"first","affiliation":[{"name":"Department of Thoracic Surgery Centre Hospitalier du Valais Romand (CHVR)  Sion Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louis\u2010Emmanuel","family":"Chriqui","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery Lausanne University Hospital (CHUV)  Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Etienne","family":"Abdelnour\u2010Berchtold","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery Lausanne University Hospital (CHUV)  Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthieu","family":"Zellweger","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery Lausanne University Hospital (CHUV)  Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean Yannis","family":"Perentes","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery Lausanne University Hospital (CHUV)  Lausanne Switzerland"},{"name":"Faculty of Biology and Medicine, University of Lausanne (UNIL)  Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thorsten","family":"Krueger","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery Lausanne University Hospital (CHUV)  Lausanne Switzerland"},{"name":"Faculty of Biology and Medicine, University of Lausanne (UNIL)  Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8705-4279","authenticated-orcid":false,"given":"Michel","family":"Gonzalez","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery Lausanne University Hospital (CHUV)  Lausanne 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