{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:42:32Z","timestamp":1787013752803,"version":"build-2736575974"},"reference-count":20,"publisher":"Wiley","issue":"16","license":[{"start":{"date-parts":[[2025,8,21]],"date-time":"2025-08-21T00:00:00Z","timestamp":1755734400000},"content-version":"vor","delay-in-days":20,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Thoracic Cancer"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Patients with advanced lung cancer are candidates for systemic therapies. In the context of improved tumor responses and prolonged survival periods, the treatment of tumor\/therapy\u2010related complications must be taken into account. Rescue surgery consists of a surgical resection without oncologic purpose but with the aim of controlling an acute and life\u2010threatening complication. We evaluated the postoperative outcomes of patients with advanced stage lung cancer who underwent rescue surgery for tumor or therapy\u2010related life\u2010threatening complications. We conducted a systematic review of literature using PubMed, Scopus, Embase, and Google Scholar using following keywords: (\u201crescue surgery\u201d or \u201csalvage surgery\u201d or \u201csalvage lung resection\u201d) and (\u201clung cancer\u201d or \u201cnon\u2010small cell lung cancer\u201d or \u201cNSCLC\u201d or \u201cSCLC\u201d). The primary outcome was overall survival. Secondary outcomes were the morbidity and mortality. Nine articles were included in our review for a total of 64 patients. The most common indications for rescue surgery were lung abscess, post\u2010obstructive pneumonia, hemoptysis, and empyema. The lung resection consisted of lobectomy (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200931, 48%), bilobectomy (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u20095, 8%), pneumonectomy (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200911, 17%), sleeve pneumonectomy (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200915, 23%), sleeve lobectomy (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u20091, 2%), and segmentectomy (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u20091, 2%). The mean overall survival was 12\u2009months; the postoperative complication rate was 51%. No intraoperative deaths were observed. Rescue surgery is feasible for patients with advanced lung cancer and tumor\/therapy\u2010related life\u2010threatening complications. Rescue surgery may allow access to ulterior systemic therapies; but the risk\u2013benefit imbalance should always be taken into account, considering this as a last resort treatment.\n                  <\/jats:p>","DOI":"10.1111\/1759-7714.70151","type":"journal-article","created":{"date-parts":[[2025,8,21]],"date-time":"2025-08-21T07:29:31Z","timestamp":1755761371000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Rescue Surgery for Advanced Stage Lung Cancer: A Systematic Review"],"prefix":"10.1111","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5595-6849","authenticated-orcid":false,"given":"Beatrice","family":"Leonardi","sequence":"first","affiliation":[{"name":"Thoracic Surgery Unit University of Campania \u201cLuigi Vanvitelli\u201d  Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5129-7201","authenticated-orcid":false,"given":"Gaetana","family":"Messina","sequence":"additional","affiliation":[{"name":"Thoracic Surgery Unit University of Campania \u201cLuigi Vanvitelli\u201d  Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Vicario","sequence":"additional","affiliation":[{"name":"Thoracic Surgery Unit University of Campania \u201cLuigi Vanvitelli\u201d  Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8203-6562","authenticated-orcid":false,"given":"Davide Gerardo","family":"Pica","sequence":"additional","affiliation":[{"name":"Thoracic Surgery Unit University of Campania \u201cLuigi Vanvitelli\u201d  Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincenzo","family":"Di Filippo","sequence":"additional","affiliation":[{"name":"Thoracic Surgery Unit University of Campania \u201cLuigi Vanvitelli\u201d  Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-1328-5928","authenticated-orcid":false,"given":"Riccardo","family":"Vinciguerra","sequence":"additional","affiliation":[{"name":"Thoracic Surgery Unit University of Campania \u201cLuigi Vanvitelli\u201d  Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Capasso","sequence":"additional","affiliation":[{"name":"Thoracic Surgery Unit University of Campania \u201cLuigi Vanvitelli\u201d  Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessia","family":"Caputo","sequence":"additional","affiliation":[{"name":"Thoracic Surgery Unit University of Campania \u201cLuigi Vanvitelli\u201d  Naples 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Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina","family":"Robustelli","sequence":"additional","affiliation":[{"name":"Thoracic Surgery Unit University of Campania \u201cLuigi Vanvitelli\u201d  Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carminia Maria Della","family":"Corte","sequence":"additional","affiliation":[{"name":"Oncology Unit, Department of Precision Medicine University of Campania \u201cLuigi Vanvitelli\u201d  Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Floriana","family":"Morgillo","sequence":"additional","affiliation":[{"name":"Oncology Unit, Department of Precision Medicine University of Campania \u201cLuigi Vanvitelli\u201d  Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisa","family":"Varriale","sequence":"additional","affiliation":[{"name":"Oncology Unit Buon Consiglio Fatebenefratelli Hospital  Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Damiano","family":"Capaccio","sequence":"additional","affiliation":[{"name":"Pneumology Unit Eboli Hospital  Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Grimaldi","sequence":"additional","affiliation":[{"name":"Oncology Unit A.O.R.N. San Pio  Benevento Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8340-3184","authenticated-orcid":false,"given":"Renato","family":"Franco","sequence":"additional","affiliation":[{"name":"Pathology Unit, Department of Mental and Physical Health and Preventive Medicine University of Campania \u201cLuigi Vanvitelli\u201d  Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Luc\u00e0","sequence":"additional","affiliation":[{"name":"Pathology Unit, Department of Mental and Physical Health and Preventive Medicine University of Campania \u201cLuigi Vanvitelli\u201d  Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Vicidomini","sequence":"additional","affiliation":[{"name":"Thoracic Surgery Unit University of Campania \u201cLuigi Vanvitelli\u201d  Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0628-613X","authenticated-orcid":false,"given":"Alfonso","family":"Fiorelli","sequence":"additional","affiliation":[{"name":"Thoracic Surgery Unit University of Campania \u201cLuigi Vanvitelli\u201d  Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,8,21]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00432-024-05683-9"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2023.107253"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/1759-7714.14747"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.21037\/jtd.2017.03.88"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n71"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/jech.52.6.377"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.46658\/JBIMES-24-01"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40792-022-01371-3"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00595-024-02812-2"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/icvts\/ivac043"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13019-018-0693-x"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.14789\/jmj.JMJ23-0026-OA"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lungcan.2014.02.004"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/icvts\/ivz137"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2021.11.063"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.21037\/jtd\u201024\u20101668"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/1759-7714.14671"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.5761\/atcs.ra.16\u201000019"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/1759-7714.15027"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.3390\/healthcare10040635"}],"container-title":["Thoracic Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1759-7714.70151","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T08:46:12Z","timestamp":1756370772000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1759-7714.70151"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8]]},"references-count":20,"journal-issue":{"issue":"16","published-print":{"date-parts":[[2025,8]]}},"alternative-id":["10.1111\/1759-7714.70151"],"URL":"https:\/\/doi.org\/10.1111\/1759-7714.70151","archive":["Portico"],"relation":{},"ISSN":["1759-7706","1759-7714"],"issn-type":[{"value":"1759-7706","type":"print"},{"value":"1759-7714","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8]]},"assertion":[{"value":"2025-05-31","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-12","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-21","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70151"}}