{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T20:43:32Z","timestamp":1758055412364,"version":"3.44.0"},"reference-count":8,"publisher":"Wiley","issue":"17","license":[{"start":{"date-parts":[[2025,9,4]],"date-time":"2025-09-04T00:00:00Z","timestamp":1756944000000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Thoracic Cancer"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Chest wall sarcomas are rare and may exhibit aggressive behavior, posing diagnostic challenges\u2014particularly in young adults. Although multidisciplinary treatments involving chemotherapy, radiotherapy, and surgery are recommended, prognosis remains poor. We report a case of a 43\u2010year\u2010old man referred with left\u2010sided chest pain, dyspnea, and massive pleural effusion. Cytological analysis of the effusion and biopsy revealed small, round, atypical cells, and initial immunohistochemistry suggested Ewing sarcoma. During workup, the patient's symptoms worsened, tumor lysis syndrome developed, and he died on hospital day 28. Autopsy and extended immunohistochemical testing indicated small round cell sarcoma. Molecular analysis identified an echinoderm microtubule\u2010associated protein\u2010like 4 (<jats:italic>EML4<\/jats:italic>)\u2010anaplastic lymphoma kinase (<jats:italic>ALK<\/jats:italic>) fusion gene. The final diagnosis was small round cell sarcoma with EML4\u2010ALK fusion originating from the thoracic wall. This case highlights the importance of early presentation and timely diagnosis using next generation sequencing to facilitate targeted therapy for <jats:italic>ALK<\/jats:italic>\u2010rearranged chest wall sarcomas and improve patient outcomes.<\/jats:p>","DOI":"10.1111\/1759-7714.70160","type":"journal-article","created":{"date-parts":[[2025,9,4]],"date-time":"2025-09-04T07:39:26Z","timestamp":1756971566000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Anaplastic Lymphoma Kinase\u2010Rearranged Chest Wall\u2010Undifferentiated Small Round Cell Sarcoma With Massive Pleural Effusion and Rapid Progression: A Case With Autopsy Report"],"prefix":"10.1111","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-2450-5263","authenticated-orcid":false,"given":"Toshiki","family":"Amioka","sequence":"first","affiliation":[{"name":"Yokohama City Minato Red Cross Hospital, Respiratory Medicine  Yokohama Kanagawa 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