{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T02:43:08Z","timestamp":1789094588330,"version":"build-2803163510"},"reference-count":34,"publisher":"Wiley","issue":"21","license":[{"start":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T00:00:00Z","timestamp":1762214400000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Thoracic Cancer"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Thymoma is a rare malignant tumor originating from the thymus epithelium. In recent years, immune checkpoint inhibitors have become an indispensable treatment for cancer. However, the efficacy and adverse events of immunotherapy for thymoma have not been widely evaluated. A 53\u2010year\u2010old Chinese man who was diagnosed with metastatic B2 thymomas since March 2023. He received chemotherapy plus anlotinib for four cycles since May 5, 2023, and underwent radiotherapy from May 23, 2023 to June 30, 2023. However, the treatment was not satisfactory. Thus, we detected PD\u2010L1 expression in tumors; immunohistochemical examination on the tumor revealed a high PD\u2010L1 expression in 60% of tumor cells. He presented symptoms of palpitation, gasping, fatigue, diplopia, and eyelid ptosis. Additionally, he was found to have significantly elevated levels of serum cardiac troponin, creatine kinase, creatine kinase isoenzymes, N\u2010terminal pro brain natriuretic peptide, and anti\u2010acetylcholine receptor antibody. He was eventually diagnosed with immune\u2010related myocarditis and myasthenia gravis. Finally, the patient was discharged after treatment with glucocorticoids, immunoglobulin, and pyridostigmine. Although immune checkpoint inhibitors have achieved similar anti\u2010tumor effects in thymomas as in other solid tumors, they may be closely associated with serious immune\u2010related adverse events, so special caution is required when using immune checkpoint inhibitors in thymoma patients.<\/jats:p>","DOI":"10.1111\/1759-7714.70180","type":"journal-article","created":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T03:15:53Z","timestamp":1762312553000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Myocarditis and Myasthenia Gravis Induced by Camrelizumab in a Patient With Metastatic\n                    <scp>B2<\/scp>\n                    Thymoma: A Case Report"],"prefix":"10.1111","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-2973-1939","authenticated-orcid":false,"given":"Lingling","family":"Zhao","sequence":"first","affiliation":[{"name":"Wannan Medical College  Wuhu China"},{"name":"Department of Oncology The First People\u2019s Hospital of Hefei (The Third Affiliated Hospital of Anhui Medical University)  Hefei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Yang","sequence":"additional","affiliation":[{"name":"Lu'an Hospital of Traditional Chinese Medicine (The Fifth Affiliated Hospital of Anhui University of Chinese Medicine)  Lu'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuzhi","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Oncology The First People\u2019s Hospital of Hefei (The Third Affiliated Hospital of Anhui Medical University)  Hefei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Oncology The First People\u2019s Hospital of Hefei (The Third Affiliated Hospital of Anhui Medical University)  Hefei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Oncology The First People\u2019s Hospital of Hefei (The Third Affiliated Hospital of Anhui Medical University)  Hefei China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,11,4]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"crossref","unstructured":"E. A.Engels \u201cEpidemiology of Thymoma and Associated Malignancies \u201d5(2010):S260\u2013S265.","DOI":"10.1097\/JTO.0b013e3181f1f62d"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.25583"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2021.05.029"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers15235574"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2017.77.3184"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40425-019-0723-9"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics13193073"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.2174\/157340311799960645"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.119.013757"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11910-018-0878-7"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)30533-6"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.esmoop.2022.100419"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2015.11.016"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V96.12.3872"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.esmoop.2023.101576"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.5357"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lungcan.2019.06.015"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/ccr3.7039"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtho.2016.07.018"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1080\/15563650.2017.1401079"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000031873"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000005747"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40425-019-0774-y"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2017.05.041"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2022.0020"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000004359"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2018.02.037"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.117.030571"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.21037\/cco.2020.03.08"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(18)30457-1"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.21.01440"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2019.09.009"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.esmoop.2021.100188"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2025.0027"}],"container-title":["Thoracic Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1759-7714.70180","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,14]],"date-time":"2025-11-14T11:31:45Z","timestamp":1763119905000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1759-7714.70180"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":34,"journal-issue":{"issue":"21","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["10.1111\/1759-7714.70180"],"URL":"https:\/\/doi.org\/10.1111\/1759-7714.70180","archive":["Portico"],"relation":{},"ISSN":["1759-7706","1759-7714"],"issn-type":[{"value":"1759-7706","type":"print"},{"value":"1759-7714","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"2025-07-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-17","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-04","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70180"}}